Ayoub, Samir S.

Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action

Ayoub, S. S. (2021) · Temperature

Inflammatory mediators and NSAID effectsPain Mechanisms and Treatments

Cited by 223

Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein

Ayoub, S. S., Botting, R. M., Goorha, S., Colville-Nash, P. R., Willoughby, D. A., & Ballou, L. R. (2004) · Proceedings of the National Academy of Sciences

Thermal Regulation in MedicineInflammatory mediators and NSAID effects

Cited by 104

The involvement of a cyclooxygenase 1 gene-derived protein in the antinociceptive action of paracetamol in mice

Ayoub, S. S., Colville-Nash, P. R., Willoughby, D. A., & Botting, R. M. (2006) · European Journal of Pharmacology

Inflammatory mediators and NSAID effectsPain Mechanisms and Treatments

Cited by 79

First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid

Sharma, C., Long, J. H., Shah, S., Rahman, J., Perrett, D., Ayoub, S., & Mehta, V. (2017) · Journal of Pain Research

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 51

Increased susceptibility of annexin‐A1 null mice to nociceptive pain is indicative of a spinal antinociceptive action of annexin‐A1

Ayoub, S. S., Yazid, S., & Flower, R. J. (2008) · British Journal of Pharmacology

Pain Mechanisms and TreatmentsS100 Proteins and Annexins

Cited by 48

Paracetamol-Induced Hypothermia Is Independent of Cannabinoids and Transient Receptor Potential Vanilloid-1 and Is Not Mediated by AM404

Ayoub, S. S., Pryce, G., Seed, M. P., Bolton, C., Flower, R. J., & Baker, D. (2011) · Drug Metabolism and Disposition

Cannabis and Cannabinoid ResearchThermal Regulation in Medicine

Cited by 20

Loss of hypothermic and anti-pyretic action of paracetamol in cyclooxygenase-1 knockout mice is indicative of inhibition of cyclooxygenase-1 variant enzymes

Ayoub, S. S., & Flower, R. J. (2019) · European Journal of Pharmacology

Inflammatory mediators and NSAID effectsThermal Regulation in Medicine

Cited by 19

Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE)

Ayoub, S. S., Wood, E. G., Hassan, S.-U., & Bolton, C. (2011) · Inflammation Research

Multiple Sclerosis Research StudiesInflammatory mediators and NSAID effects

Cited by 19

Iloprost-Induced Nociception: Determination of the Site of Anti-nociceptive Action of Cyclooxygenase Inhibitors and the Involvement of Cyclooxygenase Products in Central Mechanisms of Nociception

Ayoub, S. S., & Botting, R. M. (2010) · Methods in Molecular Biology

Pain Mechanisms and TreatmentsInflammatory mediators and NSAID effects

Cited by 7

Inhibition of the diclofenac‐induced cyclooxygenase‐2 activity by paracetamol in cultured macrophages is not related to the intracellular lipid hydroperoxide tone

Ayoub, S. S., Joshi, A., Chol, M., Gilroy, D. W., & Seed, M. P. (2011) · Fundamental & Clinical Pharmacology

Inflammatory mediators and NSAID effectsAntioxidant Activity and Oxidative Stress

Cited by 4