Garbers, Christoph

Interleukin-6: designing specific therapeutics for a complex cytokine

Garbers, C., Heink, S., Korn, T., & Rose-John, S. (2018) · Nature Reviews Drug Discovery

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 643

Interleukin-6 and its receptors: a highly regulated and dynamic system

Wolf, J., Rose-John, S., & Garbers, C. (2014) · Cytokine

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 618

Targeting IL-6 trans-signalling: past, present and future prospects

Rose-John, S., Jenkins, B. J., Garbers, C., Moll, J. M., & Scheller, J. (2023) · Nature Reviews Immunology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 524

Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities

Scheller, J., Garbers, C., & Rose-John, S. (2014) · Seminars in Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 308

Therapeutic Interleukin-6 Trans-signaling Inhibition by Olamkicept (sgp130Fc) in Patients With Active Inflammatory Bowel Disease

Schreiber, S., Aden, K., Bernardes, J. P., Conrad, C., Tran, F., Höper, H., Volk, V., Mishra, N., Blase, J. I., Nikolaus, S., et al. (2021) · Gastroenterology

Inflammatory Bowel DiseaseCytokine Signaling Pathways and Interactions

Cited by 259

Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding

Garbers, C., Jänner, N., Chalaris, A., Moss, M. L., Floss, D. M., Meyer, D., Koch-Nolte, F., Rose-John, S., & Scheller, J. (2011) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtease and Inhibitor Mechanisms

Cited by 201

New insights into IL-6 family cytokines in metabolism, hepatology and gastroenterology

Giraldez, M. D., Carneros, D., Garbers, C., Rose-John, S., & Bustos, M. (2021) · Nature Reviews Gastroenterology & Hepatology

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 156

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases

Garbers, C., Monhasery, N., Aparicio-Siegmund, S., Lokau, J., Baran, P., Nowell, M. A., Jones, S. A., Rose-John, S., & Scheller, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Cytokine Signaling Pathways and InteractionsProtease and Inhibitor Mechanisms

Cited by 155

Treatment of type 2 diabetes with the designer cytokine IC7Fc

Findeisen, M., Allen, T. L., Henstridge, D. C., Kammoun, H., Brandon, A. E., Baggio, L. L., Watt, K. I., Pal, M., Cron, L., Estevez, E., et al. (2019) · Nature

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 86

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.

Effenberger, T., von der Heyde, J., Bartsch, K., Garbers, C., Schulze‐Osthoff, K., Chalaris, A., Murphy, G., Rose‐John, S., & Rabe, B. (2014) · The FASEB Journal

Telomeres, Telomerase, and SenescenceProtease and Inhibitor Mechanisms

Cited by 54