Cook, Simon J.

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road

Caunt, C. J., Sale, M. J., Smith, P. D., & Cook, S. J. (2015) · Nature Reviews Cancer

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 606

Tumour cell survival signalling by the ERK1/2 pathway

Balmanno, K., & Cook, S. J. (2009) · Cell Death & Differentiation

Melanoma and MAPK PathwaysCell death mechanisms and regulation

Cited by 484

ERK1/2‐dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl‐1 and Bcl‐xL

Ewings, K. E., Hadfield‐Moorhouse, K., Wiggins, C. M., Wickenden, J. A., Balmanno, K., Gilley, R., Degenhardt, K., White, E., & Cook, S. J. (2007) · The EMBO Journal

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 176

V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a

Carragher, L. A. S., Snell, K. R., Giblett, S. M., Aldridge, V. S. S., Patel, B., Cook, S. J., Winton, D. J., Marais, R., & Pritchard, C. A. (2010) · EMBO Molecular Medicine

Telomeres, Telomerase, and SenescenceGenetic factors in colorectal cancer

Cited by 144

Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells

Nicke, B., Bastien, J., Khanna, S. J., Warne, P. H., Cowling, V., Cook, S. J., Peters, G., Delpuech, O., Schulze, A., Berns, K., et al. (2005) · Molecular Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 108

DYRK1A-mediated cyclin D1 degradation in neural stem cells contributes to the neurogenic cortical defects in down syndrome

Najas, S., Arranz, J., Lochhead, P. A., Ashford, A. L., Oxley, D., Delabar, J. M., Cook, S. J., Barallobre, M. J., & Arbonés, M. L. (2015) · EBioMedicine

Neurogenesis and neuroplasticity mechanismsDown syndrome and intellectual disability research

Cited by 92

The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance

Sale, M. J., & Cook, S. J. (2013) · Biochemical Journal

Cell death mechanisms and regulationMelanoma and MAPK Pathways

Cited by 58

ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover

Densham, R. M., Todd, D. E., Balmanno, K., & Cook, S. J. (2008) · Cellular Signalling

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 22