Ottenhoff, Roelof

Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism

Loregger, A., Raaben, M., Nieuwenhuis, J., Tan, J. M. E., Jae, L. T., van den Hengel, L. G., Hendrix, S., van den Berg, M., Scheij, S., Song, J.-Y., et al. (2020) · Nature Communications

Cancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

Cited by 51

Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

Hendrix, S., Kingma, J., Ottenhoff, R., Valiloo, M., Svecla, M., Zijlstra, L. F., Sachdev, V., Kovac, K., Levels, J. H. M., Jongejan, A., et al. (2023) · Nature Communications

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 34

SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P

Hendrix, S., Tan, J. M. E., Ndoj, K., Kingma, J., Valiloo, M., Zijlstra, L. F., Ottenhoff, R., Seidah, N. G., Loregger, A., Kober, D. L., et al. (2024) · Molecular and Cellular Biology

Sphingolipid Metabolism and SignalingLipid metabolism and biosynthesis

Cited by 9

Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis

Sachdev, V., van Loon, N. M., Kingma, J., Ottenhoff, R., Tan, J. M. E., van den Berg, M., Duijst, S., Jongejan, A., Levels, J. H. M., Rensen, P. C. N., et al. (2026) · Molecular Metabolism

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 1