Mayeux, Patrick

Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition

Jacque, N., Ronchetti, A. M., Larrue, C., Meunier, G., Birsen, R., Willems, L., Saland, E., Decroocq, J., Maciel, T. T., Lambert, M., et al. (2015) · Blood

Cancer, Hypoxia, and MetabolismAcute Myeloid Leukemia Research

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The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

Green, A. S., Chapuis, N., Trovati Maciel, T., Willems, L., Lambert, M., Arnoult, C., Boyer, O., Bardet, V., Park, S., Foretz, M., et al. (2010) · Blood

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

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APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

Birsen, R., Larrue, C., Decroocq, J., Johnson, N., Guiraud, N., Gotanegre, M., Cantero-Aguilar, L., Grignano, E., Huynh, T., Fontenay, M., et al. (2021) · Haematologica

Ferroptosis and cancer prognosisAcute Myeloid Leukemia Research

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Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis

Forejtnikovà, H., Vieillevoye, M., Zermati, Y., Lambert, M., Pellegrino, R. M., Guihard, S., Gaudry, M., Camaschella, C., Lacombe, C., Roetto, A., et al. (2010) · Blood

Erythropoietin and Anemia TreatmentIron Metabolism and Disorders

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High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

Poulain, L., Sujobert, P., Zylbersztejn, F., Barreau, S., Stuani, L., Lambert, M., Palama, T. L., Chesnais, V, Birsen, R., Vergez, F., et al. (2017) · Leukemia

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

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A variant erythroferrone disrupts iron homeostasis in SF3B1 -mutated myelodysplastic syndrome

Bondu, S., Alary, A.-S., Lefèvre, C., Houy, A., Jung, G., Lefebvre, T., Rombaut, D., Boussaid, I., Bousta, A., Guillonneau, F., et al. (2019) · Science Translational Medicine

Acute Myeloid Leukemia ResearchIron Metabolism and Disorders

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Spi-1/PU.1 participates in erythroleukemogenesis by inhibiting apoptosis in cooperation with Epo signaling and by blocking erythroid differentiation

Rimmelé, P., Kosmider, O., Mayeux, P., Moreau-Gachelin, F., & Guillouf, C. (2007) · Blood

Acute Myeloid Leukemia ResearchErythropoietin and Anemia Treatment

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