Giavridis, Theodoros

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Eyquem, J., Mansilla-Soto, J., Giavridis, T., van der Stegen, S. J. C., Hamieh, M., Cunanan, K. M., Odak, A., Gönen, M., & Sadelain, M. (2017) · Nature

CAR-T cell therapy researchCRISPR and Genetic Engineering

Cited by 1,831

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

Giavridis, T., van der Stegen, S. J. C., Eyquem, J., Hamieh, M., Piersigilli, A., & Sadelain, M. (2018) · Nature Medicine

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 1,272

Senolytic CAR T cells reverse senescence-associated pathologies

Amor, C., Feucht, J., Leibold, J., Ho, Y.-J., Zhu, C., Alonso-Curbelo, D., Mansilla-Soto, J., Boyer, J. A., Li, X., Giavridis, T., et al. (2020) · Nature

Telomeres, Telomerase, and SenescenceCAR-T cell therapy research

Cited by 1,098

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

Mestermann, K., Giavridis, T., Weber, J., Rydzek, J., Frenz, S., Nerreter, T., Mades, A., Sadelain, M., Einsele, H., & Hudecek, M. (2019) · Science Translational Medicine

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 531

HLA-independent T cell receptors for targeting tumors with low antigen density

Mansilla-Soto, J., Eyquem, J., Haubner, S., Hamieh, M., Feucht, J., Paillon, N., Zucchetti, A. E., Li, Z., Sjöstrand, M., Lindenbergh, P. L., et al. (2022) · Nature Medicine

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 190

Disruption of SUV39H1 -Mediated H3K9 Methylation Sustains CAR T-cell Function

Jain, N., Zhao, Z., Koche, R. P., Antelope, C., Gozlan, Y., Montalbano, A., Brocks, D., Lopez, M., Dobrin, A., Shi, Y., et al. (2024) · Cancer Discovery

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 95