Xia, Yiyuan

Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

Chen, C., Liao, J., Xia, Y., Liu, X., Jones, R., Haran, J., McCormick, B., Sampson, T. R., Alam, A., & Ye, K. (2022) · Gut

Gut microbiota and healthAlzheimer's disease research and treatments

Cited by 491

Bacteroides Fragilis in the gut microbiomes of Alzheimer’s disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice

Xia, Y., Xiao, Y., Wang, Z.-H., Liu, X., Alam, A. M., Haran, J. P., McCormick, B. A., Shu, X., Wang, X., & Ye, K. (2023) · Nature Communications

Gut microbiota and healthAlzheimer's disease research and treatments

Cited by 108

High-fat diet-induced diabetes couples to Alzheimer’s disease through inflammation-activated C/EBPβ/AEP pathway

Liu, P., Wang, Z.-H., Kang, S. S., Liu, X., Xia, Y., Chan, C.-B., & Ye, K. (2022) · Molecular Psychiatry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 77

C/EBPβ/AEP is age-dependently activated in Parkinson’s disease and mediates α-synuclein in the gut and brain

Wang, H., Chen, G., Ahn, E. H., Xia, Y., Kang, S. S., Liu, X., Liu, C., Han, M.-H., Chen, S., & Ye, K. (2023) · npj Parkinson's Disease

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 71

BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease

Bao, J., Qin, M., Mahaman, Y. A. R., Zhang, B., Huang, F., Zeng, K., Xia, Y., Ke, D., Wang, Q., Liu, R., et al. (2018) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

Cited by 50

Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression

Xia, Y., Qadota, H., Wang, Z.-H., Liu, P., Liu, X., Ye, K. X., Matheny, C. J., Berglund, K., Yu, S. P., Drake, D., et al. (2022) · Science Advances

Genetics, Aging, and Longevity in Model OrganismsAlzheimer's disease research and treatments

Cited by 46

Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies

Chen, G., Kang, S. S., Wang, Z., Ahn, E. H., Xia, Y., Liu, X., Sandoval, I. M., Manfredsson, F. P., Zhang, Z., & Ye, K. (2021) · Science Advances

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 44

Neuronal ApoE4 in Alzheimer’s disease and potential therapeutic targets

Zhang, L., Xia, Y., & Gui, Y. (2023) · Frontiers in Aging Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 41

C/EBPβ/δ-secretase signaling mediates Parkinson’s disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB

Wu, Z., Xia, Y., Wang, Z., Su Kang, S., Lei, K., Liu, X., Jin, L., Wang, X., Cheng, L., & Ye, K. (2021) · Molecular Psychiatry

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 41

UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's Disease

Chen, G., Ahn, E. H., Kang, S. S., Xia, Y., Liu, X., Zhang, Z., & Ye, K. (2022) · Advanced Science

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 28

Downregulation of the HCN1 Channel Alleviates Anxiety- and Depression-Like Behaviors in Mice With Cerebral Ischemia-Reperfusion Injury by Suppressing the NLRP3 Inflammasome

Zhou, M., Tao, X., Lin, K., Leng, C., Yang, Y., Gui, Y., Sun, Y., Zhou, M., Sun, B., Xia, Y., et al. (2025) · Journal of the American Heart Association

Treatment of Major DepressionNeurological Disease Mechanisms and Treatments

Cited by 6