Obach, R. Scott

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

Owen, D. R., Allerton, C. M. N., Anderson, A. S., Aschenbrenner, L., Avery, M., Berritt, S., Boras, B., Cardin, R. D., Carlo, A., Coffman, K. J., et al. (2021) · Science

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 2,033

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

Obach, R. S. (1999) · Drug Metabolism and Disposition

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 1,232

The Prediction of Human Pharmacokinetic Parameters from Preclinical and in Vitro Metabolism Data

Obach, R. S., Baxter, J. G., Liston, T. E., Silber, B. M., Jones, B. C., Macintyre, F., Rance, D. J., & Wastall, P. (1997) · The Journal of Pharmacology and Experimental Therapeutics

Pharmacogenetics and Drug MetabolismPharmaceutical studies and practices

Cited by 987

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19

Boras, B., Jones, R. M., Anson, B. J., Arenson, D., Aschenbrenner, L., Bakowski, M. A., Beutler, N., Binder, J., Chen, E., Eng, H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory)

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 154

Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance

Lombardo, F., Waters, N. J., Argikar, U. A., Dennehy, M. K., Zhan, J., Gunduz, M., Harriman, S. P., Berellini, G., Liric Rajlic, I., & Obach, R. S. (2013) · The Journal of Clinical Pharmacology

Pharmaceutical studies and practicesPharmacogenetics and Drug Metabolism

Cited by 106

The effect of CP‐99994 on the responses to provocative motion in the cat

Lucot, J. B., Obach, R. S., McLean, S., & Watson, J. W. (1997) · British Journal of Pharmacology

Nausea and vomiting managementNeuropeptides and Animal Physiology

Cited by 48