van Deursen, Jan M.

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,876

Senescence and apoptosis: dueling or complementary cell fates?

Childs, B. G., Baker, D. J., Kirkland, J. L., Campisi, J., & van Deursen, J. M. (2014) · The EMBO Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 915

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Yamazaki, Y., Baker, D. J., Tachibana, M., Liu, C.-C., van Deursen, J. M., Brott, T. G., Bu, G., & Kanekiyo, T. (2016) · Stroke

Barrier Structure and Function StudiesTelomeres, Telomerase, and Senescence

Cited by 263

Two-Step Senescence-Focused Cancer Therapies

Sieben, C. J., Sturmlechner, I., van de Sluis, B., & van Deursen, J. M. (2018) · Trends in Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 222

p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

Baker, D. J., Weaver, R. L., & van Deursen, J. M. (2013) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 130

Therapy-Induced Senescence Drives Bone Loss

Yao, Z., Murali, B., Ren, Q., Luo, X., Faget, D. V., Cole, T., Ricci, B., Thotala, D., Monahan, J., van Deursen, J. M., et al. (2020) · Cancer Research

Telomeres, Telomerase, and SenescenceBone health and treatments

Cited by 129

Age-related decline in BubR1 impairs adult hippocampal neurogenesis

Yang, Z., Jun, H., Choi, C.-I., Yoo, K. H., Cho, C. H., Hussaini, S. M. Q., Simmons, A. J., Kim, S., van Deursen, J. M., Baker, D. J., et al. (2017) · Aging Cell

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 40

E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice

Moreno, E., Toussaint, M. J. M., van Essen, S. C., Bongiovanni, L., van Liere, E. A., Koster, M. H., Yuan, R., van Deursen, J. M., Westendorp, B., & de Bruin, A. (2021) · Hepatology

Cancer-related Molecular PathwaysLiver physiology and pathology

Cited by 37

The progeroid gene BubR1 regulates axon myelination and motor function

Choi, C.-I., Yoo, K. H., Hussaini, S. M. Q., Jeon, B. T., Welby, J., Gan, H., Scarisbrick, I. A., Zhang, Z., Baker, D. J., van Deursen, J. M., et al. (2016) · Aging

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 26

Reprogramming to pluripotency can conceal somatic cell chromosomal instability

Hamada, M., Malureanu, L. A., Wijshake, T., Zhou, W., & van Deursen, J. M. (2012) · PLoS Genetics

Pluripotent Stem Cells ResearchMicrotubule and mitosis dynamics

Cited by 16