Murphy, James M.

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Murphy, J. M., Czabotar, P. E., Hildebrand, J. M., Lucet, I. S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A. I., et al. (2013) · Immunity

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,220

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J.-M., Dobson, R. C. J., Webb, A. I., et al. (2014) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 598

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Conos, S. A., Chen, K. W., De Nardo, D., Hara, H., Whitehead, L., Núñez, G., Masters, S. L., Murphy, J. M., Schroder, K., Vaux, D. L., et al. (2017) · Proceedings of the National Academy of Sciences

Inflammasome and immune disordersCell death mechanisms and regulation

Cited by 485

The molecular basis of JAK/STAT inhibition by SOCS1

Liau, N. P. D., Laktyushin, A., Lucet, I. S., Murphy, J. M., Yao, S., Whitlock, E., Callaghan, K., Nicola, N. A., Kershaw, N. J., & Babon, J. J. (2018) · Nature Communications

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 456

Regulated necrosis in kidney ischemia-reperfusion injury

Pefanis, A., Ierino, F. L., Murphy, J. M., & Cowan, P. J. (2019) · Kidney International

Cell death mechanisms and regulationAcute Kidney Injury Research

Cited by 361

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

Kershaw, N. J., Murphy, J. M., Liau, N. P. D., Varghese, L. N., Laktyushin, A., Whitlock, E. L., Lucet, I. S., Nicola, N. A., & Babon, J. J. (2013) · Nature Structural & Molecular Biology

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 301

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S., & Nicola, N. A. (2012) · Immunity

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 279

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax

Gruszczyk, J., Kanjee, U., Chan, L.-J., Menant, S., Malleret, B., Lim, N. T. Y., Schmidt, C. Q., Mok, Y.-F., Lin, K.-M., Pearson, R. D., et al. (2018) · Science

Malaria Research and ControlErythrocyte Function and Pathophysiology

Cited by 212

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

Jacobsen, A. V., Lowes, K. N., Tanzer, M. C., Lucet, I. S., Hildebrand, J. M., Petrie, E. J., van Delft, M. F., Liu, Z., Conos, S. A., Zhang, J.-G., et al. (2016) · Cell Death & Disease

Cell death mechanisms and regulationHeat shock proteins research

Cited by 160

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

Günther, C., He, G.-W., Kremer, A. E., Murphy, J. M., Petrie, E. J., Amann, K., Vandenabeele, P., Linkermann, A., Poremba, C., Schleicher, U., et al. (2016) · Journal of Clinical Investigation

Cell death mechanisms and regulationLiver Diseases and Immunity

Cited by 157

Necroptosis induced by RIPK3 requires MLKL but not Drp1

Moujalled, D. M., Cook, W. D., Murphy, J. M., & Vaux, D. L. (2014) · Cell Death & Disease

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 103

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.

Samson, A. L., Garnish, S. E., Hildebrand, J. M., & Murphy, J. M. (2021) · Science Signaling

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 82

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

Grohmann, C., Magtoto, C. M., Walker, J. R., Chua, N. K., Gabrielyan, A., Hall, M., Cobbold, S. A., Mieruszynski, S., Brzozowski, M., Simpson, D. S., et al. (2022) · Nature Communications

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 43

Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity

Horne, C. R., Wang, T., Young, S. N., Dite, T. A., Nyvall, H. G., Suresh, S., Davies, K. A., Mather, L. J., Dagley, L. F., Manning, G., et al. (2024) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 4