Layfield, Robert

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

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Guidelines for the use and interpretation of assays for monitoring autophagy

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Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle

Greenhaff, P. L., Karagounis, L. G., Peirce, N., Simpson, E. J., Hazell, M., Layfield, R., Wackerhage, H., Smith, K., Atherton, P., Selby, A., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism

Muscle metabolism and nutritionMuscle Physiology and Disorders

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α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome

Tofaris, G. K., Layfield, R., & Spillantini, M. G. (2001) · FEBS Letters

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

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Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor

Wilkins, A., Majed, H., Layfield, R., Compston, A., & Chandran, S. (2003) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsNerve injury and regeneration

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Proteasomal degradation of tau protein

David, D. C., Layfield, R., Serpell, L., Narain, Y., Goedert, M., & Spillantini, M. G. (2002) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

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Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

Bedford, L., Hay, D., Devoy, A., Paine, S., Powe, D. G., Seth, R., Gray, T., Topham, I., Fone, K., Rezvani, N., et al. (2008) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

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Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway

Copple, I. M., Lister, A., Obeng, A. D., Kitteringham, N. R., Jenkins, R. E., Layfield, R., Foster, B. J., Goldring, C. E., & Park, B. K. (2010) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

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Boning up on autophagy: The role of autophagy in skeletal biology

Shapiro, I. M., Layfield, R., Lotz, M., Settembre, C., & Whitehouse, C. (2014) · Autophagy

Autophagy in Disease and TherapyBone Metabolism and Diseases

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Novel UBA Domain Mutations of SQSTM1 in Paget's Disease of Bone: Genotype Phenotype Correlation, Functional Analysis, and Structural Consequences

Hocking, L. J., Lucas, G. J., Daroszewska, A., Cundy, T., Nicholson, G. C., Donath, J., Walsh, J. P., Finlayson, C., Cavey, J. R., Ciani, B., et al. (2004) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesBone Tumor Diagnosis and Treatments

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Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD

Goode, A., Butler, K., Long, J., Cavey, J., Scott, D., Shaw, B., Sollenberger, J., Gell, C., Johansen, T., Oldham, N. J., et al. (2016) · Autophagy

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A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice

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Bone Metabolism and DiseasesAlkaline Phosphatase Research Studies

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New Insights Into the Role of Sequestosome 1/p62 Mutant Proteins in the Pathogenesis of Paget's Disease of Bone

Rea, S. L., Walsh, J. P., Layfield, R., Ratajczak, T., & Xu, J. (2013) · Endocrine Reviews

Bone Metabolism and DiseasesAlkaline Phosphatase Research Studies

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SQSTM1 and Paget?s Disease of Bone

Layfield, R., & Hocking, L. J. (2004) · Calcified Tissue International

Bone Metabolism and DiseasesAlkaline Phosphatase Research Studies

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Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration

Paine, S., Bedford, L., Thorpe, J. R., Mayer, R. J., Cavey, J. R., Bajaj, N., Sheppard, P. W., Lowe, J., & Layfield, R. (2009) · Neuroscience Letters

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