Pappu, Rohit V.

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

Martin, E. W., Holehouse, A. S., Peran, I., Farag, M., Incicco, J. J., Bremer, A., Grace, C. R., Soranno, A., Pappu, R. V., & Mittag, T. (2020) · Science

RNA Research and SplicingProtein Structure and Dynamics

Cited by 1,147

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

Harmon, T. S., Holehouse, A. S., Rosen, M. K., & Pappu, R. V. (2017) · eLife

RNA Research and SplicingProtein Structure and Dynamics

Cited by 713

AlphaFold and Implications for Intrinsically Disordered Proteins

Ruff, K. M., & Pappu, R. V. (2021) · Journal of Molecular Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 635

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

Hu, X., Crick, S. L., Bu, G., Frieden, C., Pappu, R. V., & Lee, J.-M. (2009) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 426

PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins

Lazar, T., Martínez-Pérez, E., Quaglia, F., Hatos, A., Chemes, L. B., Iserte, J. A., Méndez, N. A., Garrone, N. A., Saldaño, T. E., Marchetti, J., et al. (2021) · Nucleic Acids Research

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 142

Describing sequence–ensemble relationships for intrinsically disordered proteins

Mao, A. H., Lyle, N., & Pappu, R. V. (2013) · Biochemical Journal

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 135

Conformational buffering underlies functional selection in intrinsically disordered protein regions

González-Foutel, N. S., Glavina, J., Borcherds, W. M., Safranchik, M., Barrera-Vilarmau, S., Sagar, A., Estaña, A., Barozet, A., Garrone, N. A., Fernandez-Ballester, G., et al. (2022) · Nature Structural & Molecular Biology

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 118

Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria

Cohan, M. C., & Pappu, R. V. (2020) · Trends in Biochemical Sciences

Protein Structure and DynamicsRNA Research and Splicing

Cited by 104

A quantitative measure for protein conformational heterogeneity

Lyle, N., Das, R. K., & Pappu, R. V. (2013) · The Journal of Chemical Physics

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 85

Sequence-to-conformation relationships of disordered regions tethered to folded domains of proteins

Mittal, A., Holehouse, A. S., Cohan, M. C., & Pappu, R. V. (2018) · Journal of Molecular Biology

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 72

Tadpole-like conformations of Huntingtin Exon 1 are characterized by conformational heterogeneity that persists regardless of polyglutamine length

Newcombe, E. A., Ruff, K. M., Sethi, A., Ormsby, A. R., Ramdzan, Y. M., Fox, A., Purcell, A. W., Gooley, P. R., Pappu, R. V., & Hatters, D. M. (2018) · Journal of Molecular Biology

Genetic Neurodegenerative DiseasesProtein Structure and Dynamics

Cited by 66