Brownell, James E.

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Soucy, T. A., Smith, P. G., Milhollen, M. A., Berger, A. J., Gavin, J. M., Adhikari, S., Brownell, J. E., Burke, K. E., Cardin, D. P., Critchley, S., et al. (2009) · Nature

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

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Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

Kuo, M.-H., Brownell, J. E., Sobel, R. E., Ranalli, T. A., Cook, R. G., Edmondson, D. G., Roth, S. Y., & Allis, C. D. (1996) · Nature

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

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Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

Bedford, L., Lowe, J., Dick, L. R., Mayer, R. J., & Brownell, J. E. (2011) · Nature Reviews Drug Discovery

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 563

Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα

Read, M. A., Brownell, J. E., Gladysheva, T. B., Hottelet, M., Parent, L. A., Coggins, M. B., Pierce, J. W., Podust, V. N., Luo, R.-S., Chau, V., et al. (2000) · Molecular and Cellular Biology

Ubiquitin and proteasome pathwaysNF-κB Signaling Pathways

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The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy

Soucy, T. A., Dick, L. R., Smith, P. G., Milhollen, M. A., & Brownell, J. E. (2010) · Genes & Cancer

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

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