Gorkin, David

CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function

Guo, Y., Xu, Q., Canzio, D., Shou, J., Li, J., Gorkin, D. U., Jung, I., Wu, H., Zhai, Y., Tang, Y., et al. (2015) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 958

Multi-platform discovery of haplotype-resolved structural variation in human genomes

Chaisson, M. J. P., Sanders, A. D., Zhao, X., Malhotra, A., Porubsky, D., Rausch, T., Gardner, E. J., Rodriguez, O. L., Guo, L., Collins, R. L., et al. (2019) · Nature Communications

Genomic variations and chromosomal abnormalitiesGenomics and Phylogenetic Studies

Cited by 891

Chromatin Domains: The Unit of Chromosome Organization

Dixon, J. R., Gorkin, D. U., & Ren, B. (2016) · Molecular Cell

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 811

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., et al. (2022) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 704

The 3D genome in transcriptional regulation and pluripotency

Gorkin, D. U., Leung, D., & Ren, B. (2014) · Cell Stem Cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 391

Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

Preissl, S., Fang, R., Huang, H., Zhao, Y., Raviram, R., Gorkin, D. U., Zhang, Y., Sos, B. C., Afzal, V., Dickel, D. E., et al. (2018) · Nature Neuroscience

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 332

Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation

Kubo, N., Ishii, H., Xiong, X., Bianco, S., Meitinger, F., Hu, R., Hocker, J. D., Conte, M., Gorkin, D., Yu, M., et al. (2021) · Nature Structural & Molecular Biology

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 289

A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway

Praetorius, C., Grill, C., Stacey, S. N., Metcalf, A. M., Gorkin, D. U., Robinson, K. C., Van Otterloo, E., Kim, R. S. Q., Bergsteinsdottir, K., Ogmundsdottir, M. H., et al. (2013) · Cell

melanin and skin pigmentationMelanoma and MAPK Pathways

Cited by 228

Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

Chiou, J., Zeng, C., Cheng, Z., Han, J. Y., Schlichting, M., Huang, S., Wang, J., Sui, Y., Deogaygay, A., Okino, M.-L., et al. (2019) · Nature Genetics

Pancreatic function and diabetesGenomics and Chromatin Dynamics

Cited by 189

An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum

Li, Y. E., Preissl, S., Hou, X., Zhang, Z., Zhang, K., Fang, R., Qiu, Y., Poirion, O., Li, B., Liu, H., et al. (2020) · Nature

Genomics and Chromatin DynamicsSingle-cell and spatial transcriptomics

Cited by 187

An atlas of gene regulatory elements in adult mouse cerebrum

Li, Y. E., Preissl, S., Hou, X., Zhang, Z., Zhang, K., Qiu, Y., Poirion, O. B., Li, B., Chiou, J., Liu, H., et al. (2021) · Nature

Genomics and Chromatin DynamicsSingle-cell and spatial transcriptomics

Cited by 185

Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro

Seirup, M., Sengupta, S., Swanson, S., McIntosh, B. E., Collins, M., Chu, L.-F., Cheng, Z., Gorkin, D. U., Duffin, B., Bolin, J. M., et al. (2022) · Genomics

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 13