Lin, Eva

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

Wilson, T. R., Fridlyand, J., Yan, Y., Penuel, E., Burton, L., Chan, E., Peng, J., Lin, E., Wang, Y., Sosman, J., et al. (2012) · Nature

Melanoma and MAPK PathwaysLung Cancer Treatments and Mutations

Cited by 1,134

A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., & Zigmond, M. J. (2002) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 598

USP7 small-molecule inhibitors interfere with ubiquitin binding.

Kategaya, L., Di Lello, P., Rougé, L., Pastor, R., Clark, K. R., Drummond, J., Kleinheinz, T., Lin, E., Upton, J.-P., Prakash, S., et al. (2017) · Nature

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 333

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

Hagenbeek, T. J., Zbieg, J. R., Hafner, M., Mroue, R., Lacap, J. A., Sodir, N. M., Noland, C. L., Afghani, S., Kishore, A., Bhat, K. P., et al. (2023) · Nature Cancer

Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics

Cited by 215

AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

Wilson, C., Ye, X., Pham, T., Lin, E., Chan, S., McNamara, E., Neve, R. M., Belmont, L., Koeppen, H., Yauch, R. L., et al. (2014) · Cancer Research

Cancer Cells and MetastasisLung Cancer Treatments and Mutations

Cited by 150

ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma

Yen, I., Shanahan, F., Lee, J., Hong, Y. S., Shin, S. J., Moore, A. R., Sudhamsu, J., Chang, M. T., Bae, I., Dela Cruz, D., et al. (2021) · Nature

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 138

Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways

Pham, T. H., Hagenbeek, T. J., Lee, H.-J., Li, J., Rose, C. M., Lin, E., Yu, M., Martin, S. E., Piskol, R., Lacap, J. A., et al. (2021) · Cancer Discovery

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 64

Rapid activation of ERK by 6‐hydroxydopamine promotes survival of dopaminergic cells

Lin, E., Cavanaugh, J. E., Leak, R. K., Perez, R. G., & Zigmond, M. J. (2008) · Journal of Neuroscience Research

Parkinson's Disease Mechanisms and TreatmentsMelanoma and MAPK Pathways

Cited by 62

Abstract 3327: Discovery and characterization of the potent, allosteric SHP2 inhibitor GDC-1971 for the treatment of RTK/RAS driven tumors

Williams, B., Taylor, A., Orozco, O., Owen, C., Kelley, E., Lescarbeau, A., Shortsleeves, K., Kipp, R., Nguyen, V., Brophy, E., et al. (2022) · Cancer Research

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 7