Stein, Amelie

Macromolecular modeling and design in Rosetta: recent methods and frameworks

Leman, J. K., Weitzner, B. D., Lewis, S. M., Adolf-Bryfogle, J., Alam, N., Alford, R. F., Aprahamian, M., Baker, D., Barlow, K. A., Barth, P., et al. (2020) · Nature Methods

Protein Structure and DynamicsComputational Drug Discovery Methods

Cited by 888

A structural biology community assessment of AlphaFold2 applications

Akdel, M., Pires, D. E. V., Pardo, E. P., Jänes, J., Zalevsky, A. O., Mészáros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., et al. (2022) · Nature Structural & Molecular Biology

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 675

Rapid protein stability prediction using deep learning representations

Blaabjerg, L. M., Kassem, M. M., Good, L. L., Jonsson, N., Cagiada, M., Johansson, K. E., Boomsma, W., Stein, A., & Lindorff-Larsen, K. (2023) · eLife

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 177

Rapid protein stability prediction using deep learning representations

Blaabjerg, L. M., Kassem, M. M., Good, L. L., Jonsson, N., Cagiada, M., Johansson, K. E., Boomsma, W., Stein, A., & Lindorff-Larsen, K. (2022) · eLife

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 176

A structural biology community assessment of AlphaFold 2 applications

Akdel, M., Pires, D. E. V., Porta Pardo, E., Jänes, J., Zalevsky, A. O., Mészáros, B., Bryant, P., Good, L. L., Laskowski, R. A., Pozzati, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 122

A comprehensive map of human glucokinase variant activity

Gersing, S., Cagiada, M., Gebbia, M., Gjesing, A. P., Coté, A. G., Seesankar, G., Li, R., Tabet, D., Weile, J., Stein, A., et al. (2023) · Genome Biology

Pancreatic function and diabetesGenomics and Rare Diseases

Cited by 55

A mutational atlas for Parkin proteostasis

Clausen, L., Voutsinos, V., Cagiada, M., Johansson, K. E., Grønbæk-Thygesen, M., Nariya, S., Powell, R. L., Have, M. K. N., Oestergaard, V. H., Stein, A., et al. (2024) · Nature Communications

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 51

Interpreting the molecular mechanisms of disease variants in human transmembrane proteins

Tiemann, J. K. S., Zschach, H., Lindorff-Larsen, K., & Stein, A. (2022) · Biophysical Journal

Genomics and Rare DiseasesProtein Structure and Dynamics

Cited by 35

Interpreting the molecular mechanisms of disease variants in human transmembrane proteins

Tiemann, J. K. S., Zschach, H., Lindorff-Larsen, K., & Stein, A. (2023) · Biophysical Journal

Genomics and Rare DiseasesProtein Structure and Dynamics

Cited by 35

MutationExplorer : a webserver for mutation of proteins and 3D visualization of energetic impacts

Philipp, M., Moth, C. W., Ristic, N., Tiemann, J. K. S., Seufert, F., Panfilova, A., Meiler, J., Hildebrand, P. W., Stein, A., Wiegreffe, D., et al. (2024) · Nucleic Acids Research

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 35

Accurate protein stability predictions from homology models

Valanciute, A., Nygaard, L., Zschach, H., Maglegaard Jepsen, M., Lindorff-Larsen, K., & Stein, A. (2023) · Computational and Structural Biotechnology Journal

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 33

Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

Gersing, S., Schulze, T. K., Cagiada, M., Stein, A., Roth, F. P., Lindorff-Larsen, K., & Hartmann-Petersen, R. (2024) · Genome Biology

Pancreatic function and diabetesGenomics and Rare Diseases

Cited by 23

Systematic characterization of indel variants using a yeast-based protein folding sensor

Larsen-Ledet, S., Lindemose, S., Panfilova, A., Gersing, S., Suhr, C. H., Genzor, A. V., Lanters, H., Nielsen, S. V., Lindorff-Larsen, K., Winther, J. R., et al. (2024) · Structure

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 3

Systematic characterization of indel variants using a yeast-based protein folding sensor

Larsen-Ledet, S., Lindemose, S., Panfilova, A., Gersing, S., Suhr, C. H., Genzor, A. V., Lanters, H., Nielsen, S. V., Lindorff-Larsen, K., Winther, J. R., et al. (2025) · Structure

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 3