Lau, Jesper

Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide

Lau, J., Bloch, P., Schäffer, L., Pettersson, I., Spetzler, J., Kofoed, J., Madsen, K., Knudsen, L. B., McGuire, J., Steensgaard, D. B., et al. (2015) · Journal of Medicinal Chemistry

Diabetes Treatment and ManagementChemical Synthesis and Analysis

Cited by 1,105

The Discovery and Development of Liraglutide and Semaglutide

Knudsen, L. B., & Lau, J. (2019) · Frontiers in Endocrinology

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 970

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

Graaf, C. D., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J.-M., Liao, J., Fletcher, M. M., Yang, D., et al. (2016) · Pharmacological Reviews

Receptor Mechanisms and SignalingDiabetes Treatment and Management

Cited by 403

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

Song, G., Yang, D., Wang, Y., de Graaf, C., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., et al. (2017) · Nature

Receptor Mechanisms and SignalingDiabetes Treatment and Management

Cited by 241

Small-molecule agonists for the glucagon-like peptide 1 receptor

Knudsen, L. B., Kiel, D., Teng, M., Behrens, C., Bhumralkar, D., Kodra, J. T., Holst, J. J., Jeppesen, C. B., Johnson, M. D., de Jong, J. C., et al. (2007) · Proceedings of the National Academy of Sciences

Diabetes Treatment and ManagementReceptor Mechanisms and Signaling

Cited by 232

Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: translational difficulties and pitfalls

Simonsen, L., Lau, J., Kruse, T., Guo, T., McGuire, J., Jeppesen, J. F., Niss, K., Sauerberg, P., Raun, K., & Dornonville de la Cour, C. (2022) · PLOS ONE

Diabetes Treatment and ManagementPharmacology and Obesity Treatment

Cited by 36