Freund, Adam

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 2,232

Inflammatory networks during cellular senescence: causes and consequences.

Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,354

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,275

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Laberge, R.-M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., et al. (2015) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,160

Lamin B1 loss is a senescence-associated biomarker

Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 1,046

p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype

Freund, A., Patil, C. K., & Campisi, J. (2011) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,039

Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

Coppé, J.-P., Rodier, F., Patil, C. K., Freund, A., Desprez, P.-Y., & Campisi, J. (2011) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 506

Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype

Laberge, R., Zhou, L., Sarantos, M. R., Rodier, F., Freund, A., de Keizer, P. L. J., Liu, S., Demaria, M., Cong, Y., Kapahi, P., et al. (2012) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 229

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

Di Francesco, A., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Schott, W., Wright, K. M., et al. (2023) · Nature

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 194

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

Churchill, G., Francesco, A. D., Deighan, A., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Schott, W., et al. (2024) · Nature

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 194

Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging

Muñoz, D. P., Yannone, S. M., Daemen, A., Sun, Y., Vakar-Lopez, F., Kawahara, M., Freund, A. M., Rodier, F., Wu, J. D., Desprez, P.-Y., et al. (2019) · JCI Insight

Telomeres, Telomerase, and SenescenceImmune Cell Function and Interaction

Cited by 162