Nogales, Eva

Structures of Cas9 endonucleases reveal RNA-mediated conformational activation

Jinek, M., Jiang, F., Taylor, D. W., Sternberg, S. H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., et al. (2014) · Science

CRISPR and Genetic EngineeringEnzyme Structure and Function

Cited by 1,230

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

Alushin, G. M., Lander, G. C., Kellogg, E. H., Zhang, R., Baker, D., & Nogales, E. (2014) · Cell

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 696

Complete subunit architecture of the proteasome regulatory particle

Lander, G. C., Estrin, E., Matyskiela, M. E., Bashore, C., Nogales, E., & Martin, A. (2012) · Nature

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 608

Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins

Zhang, R., Alushin, G. M., Brown, A., & Nogales, E. (2015) · Cell

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 457

CasX enzymes comprise a distinct family of RNA-guided genome editors

Liu, J.-J., Orlova, N., Oakes, B. L., Ma, E., Spinner, H. B., Baney, K. L. M., Chuck, J., Tan, D., Knott, G. J., Harrington, L. B., et al. (2019) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 446

Near-atomic model of microtubule-tau interactions

Kellogg, E. H., Hejab, N. M. A., Poepsel, S., Downing, K. H., DiMaio, F., & Nogales, E. (2018) · Science

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 416

Enhanced FIB-SEM systems for large-volume 3D imaging

Xu, C. S., Hayworth, K. J., Lu, Z., Grob, P., Hassan, A. M., García-Cerdán, J. G., Niyogi, K. K., Nogales, E., Weinberg, R. J., & Hess, H. F. (2017) · eLife

Advanced Electron Microscopy Techniques and ApplicationsAdvanced Materials Characterization Techniques

Cited by 411

Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures

Kellogg, E. H., Hejab, N. M. A., Howes, S., Northcote, P., Miller, J. H., Díaz, J. F., Downing, K. H., & Nogales, E. (2017) · Journal of Molecular Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 234

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure

Howes, S. C., Alushin, G. M., Shida, T., Nachury, M. V., & Nogales, E. (2014) · Molecular Biology of the Cell

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 183

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

Diao, J., Grob, P., Cipriano, D. J., Kyoung, M., Zhang, Y., Shah, S., Nguyen, A., Padolina, M., Srivastava, A., Vrljic, M., et al. (2012) · eLife

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 170

Separating the effects of nucleotide and EB binding on microtubule structure

Zhang, R., LaFrance, B., & Nogales, E. (2018) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 160

In vitro system capable of differentiating fast Ca 2+ -triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

Kyoung, M., Srivastava, A., Zhang, Y., Diao, J., Vrljic, M., Grob, P., Nogales, E., Chu, S., & Brunger, A. T. (2011) · Proceedings of the National Academy of Sciences

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 154

A Mutation in γ-Tubulin Alters Microtubule Dynamics and Organization and Is Synthetically Lethal with the Kinesin-like Protein Pkl1p

Paluh, J. L., Nogales, E., Oakley, B. R., McDonald, K., Pidoux, A. L., & Cande, W. Z. (2000) · Molecular Biology of the Cell

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 125

Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7

Ferro, L. S., Fang, Q., Eshun-Wilson, L., Fernandes, J., Jack, A., Farrell, D. P., Golcuk, M., Huijben, T., Costa, K., Gur, M., et al. (2022) · Science

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 112

Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae

Bertin, A., McMurray, M. A., Pierson, J., Thai, L., McDonald, K. L., Zehr, E. A., García, G., Peters, P., Thorner, J., & Nogales, E. (2012) · Molecular Biology of the Cell

Fungal and yeast genetics researchMicrotubule and mitosis dynamics

Cited by 106

Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules

LaFrance, B. J., Roostalu, J., Henkin, G., Greber, B. J., Zhang, R., Normanno, D., McCollum, C. O., Surrey, T., & Nogales, E. (2022) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 100

Structural differences between yeast and mammalian microtubules revealed by cryo-EM

Howes, S. C., Geyer, E. A., LaFrance, B., Zhang, R., Kellogg, E. H., Westermann, S., Rice, L. M., & Nogales, E. (2017) · Journal of Cell Biology

Microtubule and mitosis dynamicsGenetic and Kidney Cyst Diseases

Cited by 89

Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts

Ghanim, G. E., Kellogg, E. H., Nogales, E., & Rio, D. C. (2019) · Nature Structural & Molecular Biology

Chromosomal and Genetic VariationsGenomics and Chromatin Dynamics

Cited by 37

Structure and flexibility of the yeast NuA4 histone acetyltransferase complex

Zukin, S. A., Marunde, M. R., Popova, I. K., Soczek, K. M., Nogales, E., & Patel, A. B. (2022) · eLife

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 22

Structure and Flexibility of the Yeast NuA4 Histone Acetyltransferase Complex

Zukin, S. A., Marunde, M. R., Popova, I. K., Nogales, E., & Patel, A. B. (2022) · eLife

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 22

Molecular interplay between HURP and Kif18A in mitotic spindle regulation

Nogales, E., Perez-Bertoldi, J., Zhao, Y., Thawani, A., & Yildiz, A. (2024) · Nature Communications

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 6