Bak, Rasmus O.

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

Hendel, A., Bak, R. O., Clark, J. T., Kennedy, A. B., Ryan, D. E., Roy, S., Steinfeld, I., Lunstad, B. D., Kaiser, R. J., Wilkens, A. B., et al. (2015) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 1,090

Activation of proto-oncogenes by disruption of chromosome neighborhoods

Hnisz, D., Weintraub, A. S., Day, D. S., Valton, A.-L., Bak, R. O., Li, C. H., Goldmann, J., Lajoie, B. R., Fan, Z. P., Sigova, A. A., et al. (2016) · Science

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 1,042

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

Dever, D. P., Bak, R. O., Reinisch, A., Camarena, J., Washington, G., Nicolas, C. E., Pavel-Dinu, M., Saxena, N., Wilkens, A. B., Mantri, S., et al. (2016) · Nature

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 864

A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells

Vakulskas, C. A., Dever, D. P., Rettig, G. R., Turk, R., Jacobi, A. M., Collingwood, M. A., Bode, N. M., McNeill, M. S., Yan, S., Camarena, J., et al. (2018) · Nature Medicine

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 782

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

Jakobsen, M. R., Bak, R. O., Andersen, A., Berg, R. K., Jensen, S. B., Jin, T., Laustsen, A., Hansen, K., Østergaard, L., Fitzgerald, K. A., et al. (2013) · Proceedings of the National Academy of Sciences

interferon and immune responsesHIV Research and Treatment

Cited by 344

CRISPR/Cas9 genome editing in human hematopoietic stem cells.

Bak, R. O., Dever, D. P., & Porteus, M. H. (2018) · Nature Protocols

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 319

Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6

Bak, R. O., Dever, D. P., Reinisch, A., Cruz Hernandez, D., Majeti, R., & Porteus, M. H. (2017) · eLife

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 122

Managing MicroRNAs with Vector-Encoded Decoy-Type Inhibitors

Bak, R. O., Hollensen, A. K., & Mikkelsen, J. G. (2013) · Molecular Therapy

RNA Interference and Gene DeliveryMicroRNA in disease regulation

Cited by 49

Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified SgRNAs

Holmgaard, A. B., Askou, A. L., Jensen, E. G., Alsing, S., Bak, R. O., Mikkelsen, J. G., & Corydon, T. J. (2021) · Molecular Therapy

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 36

The p53 challenge of hematopoietic stem cell gene editing

Dorset, S. R., & Bak, R. O. (2023) · Molecular Therapy - Methods & Clinical Development

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 33

A simultaneous knockout knockin genome editing strategy in HSPCs potently inhibits CCR5- and CXCR4-tropic HIV-1 infection

Dudek, A. M., Feist, W. N., Sasu, E. J., Luna, S. E., Ben-Efraim, K., Bak, R. O., Cepika, A.-M., & Porteus, M. H. (2024) · Cell Stem Cell

HIV Research and TreatmentCRISPR and Genetic Engineering

Cited by 19