Tian, Ruilin

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

Guo, X., Aviles, G., Liu, Y., Tian, R., Unger, B. A., Lin, Y.-H. T., Wiita, A. P., Xu, K., Correia, M. A., & Kampmann, M. (2020) · Nature

Endoplasmic Reticulum Stress and DiseaseMitochondrial Function and Pathology

Cited by 674

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

Tian, R., Gachechiladze, M. A., Ludwig, C. H., Laurie, M. T., Hong, J. Y., Nathaniel, D., Prabhu, A. V., Fernandopulle, M. S., Patel, R., Abshari, M., et al. (2019) · Neuron

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 543

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian, R., Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Dräger, N., Leng, K., Nalls, M. A., Singleton, A. B., Xu, K., et al. (2020) · Nature Neuroscience

CRISPR and Genetic EngineeringFerroptosis and cancer prognosis

Cited by 414

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian, R., Abarientos, A., Hong, J., Hashemi, S. H., Yan, R., Dräger, N., Leng, K., Nalls, M. A., Singleton, A. B., Xu, K., et al. (2021) · Nature Neuroscience

CRISPR and Genetic EngineeringFerroptosis and cancer prognosis

Cited by 414

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

Chen, J. J., Nathaniel, D. L., Raghavan, P., Nelson, M., Tian, R., Tse, E., Hong, J. Y., See, S. K., Mok, S.-A., Hein, M. Y., et al. (2019) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 170

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

Torres, S. E., Gallagher, C. M., Plate, L., Gupta, M., Liem, C. R., Guo, X., Tian, R., Stroud, R. M., Kampmann, M., Weissman, J. S., et al. (2019) · eLife

Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Cited by 76