Claridge, Timothy D. W.

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Chowdhury, R., Yeoh, K. K., Tian, Y., Hillringhaus, L., Bagg, E. A., Rose, N. R., Leung, I. K. H., Li, X. S., Woon, E. C. Y., Yang, M., et al. (2011) · The EMBO Reports

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 1,035

Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

Hon, W.-C., Wilson, M. I., Harlos, K., Claridge, T. D. W., Schofield, C. J., Pugh, C. W., Maxwell, P. H., Ratcliffe, P. J., Stuart, D. I., & Jones, E. Y. (2002) · Nature

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 751

Aromatic and antiaromatic ring currents in a molecular nanoring

Peeks, M. D., Claridge, T. D. W., & Anderson, H. L. (2017) · Nature

Synthesis and Properties of Aromatic CompoundsPorphyrin and Phthalocyanine Chemistry

Cited by 277

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

McNEILL, L. A., HEWITSON, K. S., CLARIDGE, T. D., SEIBEL, J. F., HORSFALL, L. E., & SCHOFIELD, C. J. (2002) · Biochemical Journal

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 215

Global aromaticity at the nanoscale

Rickhaus, M., Jirasek, M., Tejerina, L., Gotfredsen, H., Peeks, M. D., Haver, R., Jiang, H.-W., Claridge, T. D. W., & Anderson, H. L. (2020) · Nature Chemistry

Synthesis and Properties of Aromatic CompoundsPorphyrin and Phthalocyanine Chemistry

Cited by 175

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

Ge, W., Wolf, A., Feng, T., Ho, C.-H., Sekirnik, R., Zayer, A., Granatino, N., Cockman, M. E., Loenarz, C., Loik, N. D., et al. (2012) · Nature Chemical Biology

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 154

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Chowdhury, R., Leung, I. K. H., Tian, Y.-M., Abboud, M. I., Ge, W., Domene, C., Cantrelle, F.-X., Landrieu, I., Hardy, A. P., Pugh, C. W., et al. (2016) · Nature Communications

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 145

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases

Tarhonskaya, H., Rydzik, A. M., Leung, I. K. H., Loik, N. D., Chan, M. C., Kawamura, A., McCullagh, J. S. O., Claridge, T. D. W., Flashman, E., & Schofield, C. J. (2014) · Nature Communications

Metal-Catalyzed Oxygenation MechanismsCancer, Hypoxia, and Metabolism

Cited by 80

Global Aromaticity and Antiaromaticity in Porphyrin Nanoring Anions

Peeks, M. D., Jirasek, M., Claridge, T. D. W., & Anderson, H. L. (2019) · Angewandte Chemie International Edition

Synthesis and Properties of Aromatic CompoundsPorphyrin and Phthalocyanine Chemistry

Cited by 49