Newby, Gregory A.

Search-and-replace genome editing without double-strand breaks or donor DNA

Anzalone, A. V., Randolph, P. B., Davis, J. R., Sousa, A. A., Koblan, L. W., Levy, J. M., Chen, P. J., Wilson, C., Newby, G. A., Raguram, A., et al. (2019) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

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Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Richter, M. F., Zhao, K. T., Eton, E., Lapinaite, A., Newby, G. A., Thuronyi, B. W., Wilson, C., Koblan, L. W., Zeng, J., Bauer, D. E., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,020

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

Koblan, L. W., Doman, J. L., Wilson, C., Levy, J. M., Tay, T., Newby, G. A., Maianti, J. P., Raguram, A., & Liu, D. R. (2018) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 944

Engineered pegRNAs improve prime editing efficiency

Nelson, J. W., Randolph, P. B., Shen, S. P., Everette, K. A., Chen, P. J., Anzalone, A. V., An, M., Newby, G. A., Chen, J. C., Hsu, A., et al. (2022) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 727

Engineered Virus-like Particles for Efficient in Vivo Delivery of Therapeutic Proteins

Banskota, S., Raguram, A., Suh, S., Du, S. W., Davis, J. R., Choi, E. H., Wang, X., Nielsen, S. C., Newby, G. A., Randolph, P. B., et al. (2022) · Cell

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 668

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

Doman, J. L., Raguram, A., Newby, G. A., & Liu, D. R. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 473

Continuous evolution of base editors with expanded target compatibility and improved activity

Thuronyi, B. W., Koblan, L. W., Levy, J. M., Yeh, W.-H., Zheng, C., Newby, G. A., Wilson, C., Bhaumik, M., Shubina-Oleinik, O., Holt, J. R., et al. (2019) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 347

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., et al. (2019) · Molecular Cell

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

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Precision genome editing using cytosine and adenine base editors in mammalian cells

Huang, T. P., Newby, G. A., & Liu, D. R. (2021) · Nature Protocols

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 175

In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice

Du, S. W., Newby, G. A., Salom, D., Gao, F., Menezes, C. R., Suh, S., Choi, E. H., Chen, P. Z., Liu, D. R., & Palczewski, K. (2024) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersCRISPR and Genetic Engineering

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