Lees, Emma

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

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Project DRIVE: a compendium of cancer dependencies and synthetic lethal relationships uncovered by large-scale, deep RNAi screening

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

Townsend, E. C., Murakami, M. A., Christodoulou, A., Christie, A. L., Köster, J., DeSouza, T. A., Morgan, E. A., Kallgren, S. P., Liu, H., Wu, S.-C., et al. (2016) · Cancer Cell

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Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

Dulić, V, Drullinger, L. F., Lees, E., Reed, S. I., & Stein, G. H. (1993) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

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Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors

Parry, D., Mahony, D., Wills, K., & Lees, E. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

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The public repository of xenografts enables discovery and randomized phase II-like trials in mice

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