Safe, Stephen

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology

Estrogen and related hormone effectsEffects and risks of endocrine disrupting chemicals

Cited by 4,203

The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-like Compounds

Van den Berg, M., Birnbaum, L. S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., et al. (2006) · Toxicological Sciences

Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

Cited by 3,785

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

Safe, S. (1990) · Critical Reviews in Toxicology

Toxic Organic Pollutants ImpactEnvironmental Toxicology and Ecotoxicology

Cited by 1,871

A Novel Regulator of Macrophage Activation: miR-223 in Obesity-Associated Adipose Tissue Inflammation

Zhuang, G., Meng, C., Guo, X., Cheruku, P. S., Shi, L., Xu, H., Li, H., Wang, G., Evans, A. R., Safe, S., et al. (2012) · Circulation

Adipokines, Inflammation, and Metabolic DiseasesMicroRNA in disease regulation

Cited by 428

Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways

Safe, S., & Kim, K. (2008) · Journal of Molecular Endocrinology

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 368

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation

Ying, W., Tseng, A., Chang, R. C.-A., Morin, A., Brehm, T., Triff, K., Nair, V., Zhuang, G., Song, H., Kanameni, S., et al. (2015) · Journal of Clinical Investigation

Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Cited by 144

Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer

Nair, V., Sreevalsan, S., Basha, R., Abdelrahim, M., Abudayyeh, A., Rodrigues Hoffman, A., & Safe, S. (2014) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 129

Aspirin Inhibits Colon Cancer Cell and Tumor Growth and Downregulates Specificity Protein (Sp) Transcription Factors

Pathi, S., Jutooru, I., Chadalapaka, G., Nair, V., Lee, S.-O., & Safe, S. (2012) · PLoS ONE

Inflammatory mediators and NSAID effectsHistone Deacetylase Inhibitors Research

Cited by 127

Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice

Wu, C.-S., Wei, Q., Wang, H., Kim, D. M., Balderas, M., Wu, G., Lawler, J., Safe, S., Guo, S., Devaraj, S., et al. (2020) · The Journals of Gerontology: Series A

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 81

Editor’s Highlight: Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure–Activity Relationships and Receptor Modeling

Cheng, Y., Jin, U.-H., Davidson, L. A., Chapkin, R. S., Jayaraman, A., Tamamis, P., Orr, A., Allred, C., Denison, M. S., Soshilov, A., et al. (2017) · Toxicological Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 48

PAH Particles Perturb Prenatal Processes and Phenotypes: Protection from Deficits in Object Discrimination Afforded by Dampening of Brain Oxidoreductase Following In Utero Exposure to Inhaled Benzo(a)pyrene

Li, Z., Chadalapaka, G., Ramesh, A., Khoshbouei, H., Maguire, M., Safe, S., Rhoades, R. E., Clark, R., Jules, G., McCallister, M., et al. (2012) · Toxicological Sciences

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 29

Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells

Mohankumar, K., Lee, J., Wu, C. S., Sun, Y., & Safe, S. (2018) · Endocrinology

Metabolism, Diabetes, and CancerNuclear Receptors and Signaling

Cited by 24