Cain, Kelvin

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Dickens, L. S., Boyd, R. S., Jukes-Jones, R., Hughes, M. A., Robinson, G. L., Fairall, L., Schwabe, J. W. R., Cain, K., & MacFarlane, M. (2012) · Molecular Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 349

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

Hughes, M. A., Powley, I. R., Jukes-Jones, R., Horn, S., Feoktistova, M., Fairall, L., Schwabe, J. W. R., Leverkus, M., Cain, K., & MacFarlane, M. (2016) · Molecular Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 257

Characterization of novel markers of senescence and their prognostic potential in cancer

Althubiti, M., Lezina, L., Carrera, S., Jukes-Jones, R., Giblett, S. M., Antonov, A., Barlev, N., Saldanha, G. S., Pritchard, C. A., Cain, K., et al. (2014) · Cell Death & Disease

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 256

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

Capasso, M., Bhamrah, M. K., Henley, T., Boyd, R. S., Langlais, C., Cain, K., Dinsdale, D., Pulford, K., Khan, M., Musset, B., et al. (2010) · Nature Immunology

T-cell and B-cell ImmunologyIon channel regulation and function

Cited by 223

Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease

Richards, P., Didszun, C., Campesan, S., Simpson, A., Horley, B., Young, K. W., Glynn, P., Cain, K., Kyriacou, C. P., Giorgini, F., et al. (2011) · Cell Death & Differentiation

Genetic Neurodegenerative DiseasesCellular transport and secretion

Cited by 82

Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex

Powley, I. R., Hughes, M. A., Cain, K., & MacFarlane, M. (2016) · Oncogene

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 54