Lombardo, Angelo

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

Lombardo, A., Genovese, P., Beausejour, C. M., Colleoni, S., Lee, Y.-L., Kim, K. A., Ando, D., Urnov, F. D., Galli, C., Gregory, P. D., et al. (2007) · Nature Biotechnology

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 845

Targeted genome editing in human repopulating haematopoietic stem cells

Genovese, P., Schiroli, G., Escobar, G., Di Tomaso, T., Firrito, C., Calabria, A., Moi, D., Mazzieri, R., Bonini, C., Holmes, M. C., et al. (2014) · Nature

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 555

An unbiased genome-wide analysis of zinc-finger nuclease specificity

Gabriel, R., Lombardo, A., Arens, A., Miller, J. C., Genovese, P., Kaeppel, C., Nowrouzi, A., Bartholomae, C. C., Wang, J., Friedman, G., et al. (2011) · Nature Biotechnology

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 526

Inheritable silencing of endogenous genes by hit-and-run targeted epigenetic editing

Amabile, A., Migliara, A., Capasso, P., Biffi, M., Cittaro, D., Naldini, L., & Lombardo, A. (2016) · Cell

Epigenetics and DNA MethylationCRISPR and Genetic Engineering

Cited by 516

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

Provasi, E., Genovese, P., Lombardo, A., Magnani, Z., Liu, P.-Q., Reik, A., Chu, V., Paschon, D. E., Zhang, L., Kuball, J., et al. (2012) · Nature Medicine

CAR-T cell therapy researchCRISPR and Genetic Engineering

Cited by 448

A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice

Brown, B. D., Cantore, A., Annoni, A., Sergi, L. S., Lombardo, A., Della Valle, P., D'Angelo, A., & Naldini, L. (2007) · Blood

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 252

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1

Schiroli, G., Ferrari, S., Conway, A., Jacob, A., Capo, V., Albano, L., Plati, T., Castiello, M. C., Sanvito, F., Gennery, A. R., et al. (2017) · Science Translational Medicine

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 214

iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF

Laterza, C., Merlini, A., De Feo, D., Ruffini, F., Menon, R., Onorati, M., Fredrickx, E., Muzio, L., Lombardo, A., Comi, G., et al. (2013) · Nature Communications

Multiple Sclerosis Research StudiesPluripotent Stem Cells Research

Cited by 121

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

Giordano, A. M. S., Luciani, M., Gatto, F., Abou Alezz, M., Beghè, C., Della Volpe, L., Migliara, A., Valsoni, S., Genua, M., Dzieciatkowska, M., et al. (2022) · Journal of Experimental Medicine

interferon and immune responsesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 76

Genome editing for scalable production of alloantigen‐free lentiviral vectors for in vivo gene therapy

Milani, M., Annoni, A., Bartolaccini, S., Biffi, M., Russo, F., Di Tomaso, T., Raimondi, A., Lengler, J., Holmes, M. C., Scheiflinger, F., et al. (2017) · EMBO Molecular Medicine

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 72