Nerlov, Claus

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 689

A CREB-C/EBPβ cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

Ruffell, D., Mourkioti, F., Gambardella, A., Kirstetter, P., Lopez, R. G., Rosenthal, N., & Nerlov, C. (2009) · Proceedings of the National Academy of Sciences

Immune cells in cancerMuscle Physiology and Disorders

Cited by 626

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Bröske, A.-M., Vockentanz, L., Kharazi, S., Huska, M. R., Mancini, E., Scheller, M., Kuhl, C., Enns, A., Prinz, M., Jaenisch, R., et al. (2009) · Nature Genetics

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 478

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

Nerlov, C., & Graf, T. (1998) · Genes & Development

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 449

GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription

Nerlov, C., Querfurth, E., Kulessa, H., & Graf, T. (2000) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 366

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging

Ho, Y.-H., del Toro, R., Rivera-Torres, J., Rak, J., Korn, C., García-García, A., Macías, D., González-Gómez, C., del Monte, A., Wittner, M., et al. (2019) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 315

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

Weischenfeldt, J., Damgaard, I., Bryder, D., Theilgaard-Mönch, K., Thoren, L. A., Nielsen, F. C., Jacobsen, S. E. W., Nerlov, C., & Porse, B. T. (2008) · Genes & Development

RNA Research and SplicingHematopoietic Stem Cell Transplantation

Cited by 288

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Grebien, F., Vedadi, M., Getlik, M., Giambruno, R., Grover, A., Avellino, R., Skucha, A., Vittori, S., Kuznetsova, E., Smil, D., et al. (2015) · Nature Chemical Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 284

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

Kirstetter, P., Schuster, M. B., Bereshchenko, O., Moore, S., Dvinge, H., Kurz, E., Theilgaard-Mönch, K., Månsson, R., Pedersen, T. Å., Pabst, T., et al. (2008) · Cancer Cell

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 251

Balance of MafB and PU. 1 specifies alternative macrophage or dendritic cell fate

Bakri, Y., Sarrazin, S., Mayer, U. P., Tillmanns, S., Nerlov, C., Boned, A., & Sieweke, M. H. (2005) · Blood

Immunotherapy and Immune ResponsesImmune cells in cancer

Cited by 187

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

Luc, S., Luis, T. C., Boukarabila, H., Macaulay, I. C., Buza-Vidas, N., Bouriez-Jones, T., Lutteropp, M., Woll, P. S., Loughran, S. J., Mead, A. J., et al. (2012) · Nature Immunology

T-cell and B-cell ImmunologyHematopoietic Stem Cell Transplantation

Cited by 152

Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-Initiating Cells in C/EBPα Mutant AML

Bereshchenko, O., Mancini, E., Moore, S., Bilbao, D., Månsson, R., Luc, S., Grover, A., Jacobsen, S. E. W., Bryder, D., & Nerlov, C. (2009) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 147

Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging

Jakobsen, N. A., Turkalj, S., Zeng, A. G. X., Stoilova, B., Metzner, M., Rahmig, S., Nagree, M. S., Shah, S., Moore, R., Usukhbayar, B., et al. (2024) · Cell Stem Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 130

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Valletta, S., Thomas, A., Meng, Y., Ren, X., Drissen, R., Sengül, H., Di Genua, C., & Nerlov, C. (2020) · Nature Communications

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 122

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation

Nerlov, C., McNagny, K. M., Döderlein, G., Kowenz-Leutz, E., & Graf, T. (1998) · Genes & Development

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 119

Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

Porse, B. T., Bryder, D., Theilgaard-Mönch, K., Hasemann, M. S., Anderson, K., Damgaard, I., Jacobsen, S. E. W., & Nerlov, C. (2005) · The Journal of Experimental Medicine

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 117

C/EBPα and β couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation

Lopez, R. G., Garcia-Silva, S., Moore, S. J., Bereshchenko, O., Martinez-Cruz, A. B., Ermakova, O., Kurz, E., Paramio, J. M., & Nerlov, C. (2009) · Nature Cell Biology

Skin and Cellular Biology ResearchHair Growth and Disorders

Cited by 106

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors

Buono, M., Facchini, R., Matsuoka, S., Thongjuea, S., Waithe, D., Luis, T. C., Giustacchini, A., Besmer, P., Mead, A. J., Jacobsen, S. E. W., et al. (2016) · Nature Cell Biology

T-cell and B-cell ImmunologyHematopoietic Stem Cell Transplantation

Cited by 79

Inflammatory signals directly instruct PU.1 in HSCs via TNF

Etzrodt, M., Ahmed, N., Hoppe, P. S., Loeffler, D., Skylaki, S., Hilsenbeck, O., Kokkaliaris, K. D., Kaltenbach, H.-M., Stelling, J., Nerlov, C., et al. (2019) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 67

Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1

Liew, C. W., Rand, K. D., Simpson, R. J. Y., Yung, W. W., Mansfield, R. E., Crossley, M., Proetorius-Ibba, M., Nerlov, C., Poulsen, F. M., & Mackay, J. P. (2006) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 63

CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions

Rabe, J. L., Hernandez, G., Chavez, J. S., Mills, T. S., Nerlov, C., & Pietras, E. M. (2020) · Experimental Hematology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 49

PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation

Chavez, J., Rabe, J. L., Higa, K., Loeffler, D., Nouraiz, A., Mills, T., Idler, B. M., Stevens, B. M., Fleenor, C., Nerlov, C., et al. (2019) · Blood

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 1