Smith, Paul D.
AstraZeneca (United Kingdom) · Cancer Research UK
7 papers on CoChatORCID 0000-0002-2812-5978
Most cited papers
- Verified
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study
Jänne, P. A., Shaw, A. T., Pereira, J. R., Jeannin, G., Vansteenkiste, J., Barrios, C., Franke, F. A., Grinsted, L., Zazulina, V., Smith, P., et al. (2013) · The Lancet Oncology
Lung Cancer Treatments and MutationsLung Cancer Diagnosis and Treatment
Cited by 655
- Verified
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
Caunt, C. J., Sale, M. J., Smith, P. D., & Cook, S. J. (2015) · Nature Reviews Cancer
Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling
Cited by 606
- Verified
Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
Polański, R., Hodgkinson, C. L., Fusi, A., Nonaka, D., Priest, L., Kelly, P., Trapani, F., Bishop, P. W., White, A., Critchlow, S. E., et al. (2014) · Clinical Cancer Research
Cancer, Hypoxia, and MetabolismLung Cancer Research Studies
Cited by 378
- Verified
Selumetinib Plus Docetaxel Compared With Docetaxel Alone and Progression-Free Survival in Patients With KRAS -Mutant Advanced Non–Small Cell Lung Cancer: The SELECT-1 Randomized Clinical Trial
Jänne, P. A., van den Heuvel, M. M., Barlesi, F., Cobo, M., Mazieres, J., Crinò, L., Orlov, S., Blackhall, F., Wolf, J., Garrido, P., et al. (2017) · JAMA
Lung Cancer Treatments and MutationsLung Cancer Diagnosis and Treatment
Cited by 335
- Verified
Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)
Dry, J. R., Pavey, S., Pratilas, C. A., Harbron, C., Runswick, S., Hodgson, D., Chresta, C., McCormack, R., Byrne, N., Cockerill, M., et al. (2010) · Cancer Research
Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling
Cited by 262
- Verified
BRAF V600E Disrupts AZD6244-Induced Abrogation of Negative Feedback Pathways between Extracellular Signal-Regulated Kinase and Raf Proteins
Friday, B. B., Yu, C., Dy, G. K., Smith, P. D., Wang, L., Thibodeau, S. N., & Adjei, A. A. (2008) · Cancer Research
Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling
Cited by 146
- Verified
Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in murine Kras mutant lung cancer
Choi, H., Deng, J., Li, S., Silk, T., Dong, L., Brea, E. J., Houghton, S., Redmond, D., Zhong, H., Boiarsky, J., et al. (2019) · Cell Reports
Cancer Immunotherapy and BiomarkersMelanoma and MAPK Pathways
Cited by 72
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