Irwin, Meredith S.
University of Toronto · Hospital for Sick Children
6 papers on CoChatORCID 0000-0002-2452-5181
Most cited papers
- Verified
Akt Phosphorylates the Yes-Associated Protein, YAP, to Induce Interaction with 14-3-3 and Attenuation of p73-Mediated Apoptosis
Basu, S., Totty, N. F., Irwin, M. S., Sudol, M., & Downward, J. (2003) · Molecular Cell
Hippo pathway signaling and YAP/TAZPI3K/AKT/mTOR signaling in cancer
Cited by 843
- Verified
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
Lau, L. M. S., Nugent, J. K., Zhao, X., & Irwin, M. S. (2008) · Oncogene
Cancer-related Molecular PathwaysCell death mechanisms and regulation
Cited by 182
- Verified
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
Kano, Y., Gebregiworgis, T., Marshall, C. B., Radulovich, N., Poon, B. P. K., St-Germain, J., Cook, J. D., Valencia-Sama, I., Grant, B. M. M., Herrera, S. G., et al. (2019) · Nature Communications
Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases
Cited by 103
- Verified
Suppression of Hypoxia-Inducible Factor 2α Restores p53 Activity via Hdm2 and Reverses Chemoresistance of Renal Carcinoma Cells
Roberts, A. M., Watson, I. R., Evans, A. J., Foster, D. A., Irwin, M. S., & Ohh, M. (2009) · Cancer Research
Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism
Cited by 88
- Verified
NRAS Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS–MAPK Pathway in Neuroblastoma
Valencia-Sama, I., Ladumor, Y., Kee, L., Adderley, T., Christopher, G., Robinson, C. M., Kano, Y., Ohh, M., & Irwin, M. S. (2020) · Cancer Research
Neuroblastoma Research and TreatmentsProtein Tyrosine Phosphatases
Cited by 62
- Verified
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors
Gebregiworgis, T., Kano, Y., St-Germain, J., Radulovich, N., Udaskin, M. L., Mentes, A., Huang, R., Poon, B. P. K., He, W., Valencia-Sama, I., et al. (2021) · Nature Communications
Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling
Cited by 49
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