Thakore, Pratiksha I.

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

Perez-Pinera, P., Kocak, D. D., Vockley, C. M., Adler, A. F., Kabadi, A. M., Polstein, L. R., Thakore, P. I., Glass, K. A., Ousterout, D. G., Leong, K. W., et al. (2013) · Nature Methods

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 1,328

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

Nelson, C. E., Hakim, C. H., Ousterout, D. G., Thakore, P. I., Moreb, E. A., Rivera, R. M. C., Madhavan, S., Pan, X., Ran, F. A., Yan, W. X., et al. (2016) · Science

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 1,144

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

Thakore, P. I., D'Ippolito, A. M., Song, L., Safi, A., Shivakumar, N. K., Kabadi, A. M., Reddy, T. E., Crawford, G. E., & Gersbach, C. A. (2015) · Nature Methods

CRISPR and Genetic EngineeringEpigenetics and DNA Methylation

Cited by 1,012

Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells

Mimitou, E. P., Lareau, C. A., Chen, K. Y., Zorzetto-Fernandes, A. L., Hao, Y., Takeshima, Y., Luo, W., Huang, T.-S., Yeung, B. Z., Papalexi, E., et al. (2021) · Nature Biotechnology

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 529

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

Wagner, A., Wang, C., Fessler, J., DeTomaso, D., Avila-Pacheco, J., Kaminski, J., Zaghouani, S., Christian, E., Thakore, P., Schellhaass, B., et al. (2021) · Cell

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 524

Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy

Ousterout, D. G., Kabadi, A. M., Thakore, P. I., Majoros, W. H., Reddy, T. E., & Gersbach, C. A. (2015) · Nature Communications

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 470

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Thakore, P. I., Black, J. B., Hilton, I. B., & Gersbach, C. A. (2016) · Nature Methods

CRISPR and Genetic EngineeringEpigenetics and DNA Methylation

Cited by 451

Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

Frangieh, C. J., Melms, J. C., Thakore, P. I., Geiger-Schuller, K. R., Ho, P., Luoma, A. M., Cleary, B., Jerby-Arnon, L., Malu, S., Cuoco, M. S., et al. (2021) · Nature Genetics

Cancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomics

Cited by 276

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

Schnell, A., Huang, L., Singer, M., Singaraju, A., Barilla, R. M., Regan, B. M. L., Bollhagen, A., Thakore, P. I., Dionne, D., Delorey, T. M., et al. (2021) · Cell

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 268

An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets

Zhang, H., Madi, A., Yosef, N., Chihara, N., Awasthi, A., Pot, C., Lambden, C., Srivastava, A., Burkett, P. R., Nyman, J., et al. (2020) · Cell Reports

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 91

Multiplexed, image-based pooled screens in primary cells and tissues with PerturbView

Kudo, T., Meireles, A. M., Moncada, R., Chen, Y., Wu, P., Gould, J., Hu, X., Kornfeld, O., Jesudason, R., Foo, C., et al. (2025) · Nature Biotechnology

Single-cell and spatial transcriptomicsCRISPR and Genetic Engineering

Cited by 74

The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states

Thakore, P. I., Schnell, A., Zhao, M., Huang, L., Hou, Y., Christian, E., Zaghouani, S., Wang, C., Singh, V., Ma, S., et al. (2022) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 57