Varshavsky, Alexander

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K., & Varshavsky, A. (1989) · Science

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 1,535

The N-end rule: functions, mysteries, uses

Varshavsky, A. (1996) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysAutophagy in Disease and Therapy

Cited by 859

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

Hwang, C.-S., Shemorry, A., & Varshavsky, A. (2010) · Science

Ubiquitin and proteasome pathwaysAutophagy in Disease and Therapy

Cited by 650

N-degron and C-degron pathways of protein degradation

Varshavsky, A. (2019) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 544

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit

Xie, Y., & Varshavsky, A. (2001) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 436

Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)

Zenker, M., Mayerle, J., Lerch, M. M., Tagariello, A., Zerres, K., Durie, P. R., Beier, M., Hülskamp, G., Guzman, C., Rehder, H., et al. (2005) · Nature Genetics

Ubiquitin and proteasome pathwaysGenomics and Rare Diseases

Cited by 266