Graf, Thomas

Forcing cells to change lineages

Graf, T., & Enver, T. (2009) · Nature

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 899

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

Nerlov, C., & Graf, T. (1998) · Genes & Development

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 449

GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts.

Kulessa, H., Frampton, J., & Graf, T. (1995) · Genes & Development

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 418

Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment

Miyamoto, T., Iwasaki, H., Reizis, B., Ye, M., Graf, T., Weissman, I. L., & Akashi, K. (2002) · Developmental Cell

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 415

GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription

Nerlov, C., Querfurth, E., Kulessa, H., & Graf, T. (2000) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 366

Reprogramming of Committed T Cell Progenitors to Macrophages and Dendritic Cells by C/EBPα and PU.1 Transcription Factors

Laiosa, C. V., Stadtfeld, M., Xie, H., de Andres-Aguayo, L., & Graf, T. (2006) · Immunity

T-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Cited by 351

PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells

Feng, R., Desbordes, S. C., Xie, H., Tillo, E. S., Pixley, F., Stanley, E. R., & Graf, T. (2008) · Proceedings of the National Academy of Sciences

Pluripotent Stem Cells ResearchImmune cells in cancer

Cited by 348

Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages

Arinobu, Y., Mizuno, S.-I., Chong, Y., Shigematsu, H., Iino, T., Iwasaki, H., Graf, T., Mayfield, R., Chan, S., Kastner, P., et al. (2007) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 309

MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation

Sieweke, M. H., Tekotte, H., Frampton, J., & Graf, T. (1996) · Cell

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 302

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains.

Kim, W., Sieweke, M., Ogawa, E., Wee, H., Englmeier, U., Graf, T., & Ito, Y. (1999) · The EMBO Journal

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

Cited by 230

Cell-of-origin-specific 3D genome structure acquired during somatic cell reprogramming

Krijger, P. H. L., Di Stefano, B., de Wit, E., Limone, F., van Oevelen, C., de Laat, W., & Graf, T. (2016) · Cell stem cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 217

Historical origins of transdifferentiation and reprogramming

Graf, T. (2011) · Cell Stem Cell

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 194

A transcription factor party during blood cell differentiation

Sieweke, M. H., & Graf, T. (1998) · Current Opinion in Genetics & Development

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 164

Tissue-specific control of brain-enriched miR-7 biogenesis

Choudhury, N. R., de Lima Alves, F., de Andrés-Aguayo, L., Graf, T., Cáceres, J. F., Rappsilber, J., & Michlewski, G. (2013) · Genes & Development

MicroRNA in disease regulationRNA Research and Splicing

Cited by 158

DNA binding by c‐Ets‐1, but not v‐Ets, is repressed by an intramolecular mechanism.

Lim, F., Kraut, N., Framptom, J., & Graf, T. (1992) · The EMBO Journal

Genomics and Chromatin DynamicsT-cell and Retrovirus Studies

Cited by 137

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation

Nerlov, C., McNagny, K. M., Döderlein, G., Kowenz-Leutz, E., & Graf, T. (1998) · Genes & Development

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 119

Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

Choi, J., Lysakovskaia, K., Stik, G., Demel, C., Söding, J., Tian, T. V., Graf, T., & Cramer, P. (2021) · eLife

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 117

Regulation of eosinophil‐specific gene expression by a C/EBP–Ets complex and GATA‐1

McNagny, K. M., Sieweke, M. H., Döderlein, G., Graf, T., & Nerlov, C. (1998) · The EMBO Journal

Genomics and Chromatin DynamicsAsthma and respiratory diseases

Cited by 108

Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPα-Induced Transdifferentiation of Pre-B Cells

Kallin, E. M., Rodríguez-Ubreva, J., Christensen, J., Cimmino, L., Aifantis, I., Helin, K., Ballestar, E., & Graf, T. (2012) · Molecular Cell

Epigenetics and DNA MethylationAcute Myeloid Leukemia Research

Cited by 92

NF‐M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line.

Müller, C., Kowenz‐Leutz, E., Grieser‐Ade, S., Graf, T., & Leutz, A. (1995) · The EMBO Journal

Genomics and Chromatin DynamicsAsthma and respiratory diseases

Cited by 91