Whitesell, Luke

HSP90 and the chaperoning of cancer

Whitesell, L., & Lindquist, S. L. (2005) · Nature Reviews Cancer

Heat shock proteins researchCancer-related Molecular Pathways

Cited by 2,502

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E., & Neckers, L. M. (1994) · Proceedings of the National Academy of Sciences

Heat shock proteins researchProtein Kinase Regulation and GTPase Signaling

Cited by 1,444

Mitochondrial metabolism promotes adaptation to proteotoxic stress

Tsvetkov, P., Detappe, A., Cai, K., Keys, H. R., Brune, Z., Ying, W., Thiru, P., Reidy, M., Kugener, G., Rossen, J., et al. (2019) · Nature Chemical Biology

Ubiquitin and proteasome pathwaysCell death mechanisms and regulation

Cited by 645

Widespread macromolecular interaction perturbations in human genetic disorders

Sahni, N., Yi, S., Taipale, M., Fuxman Bass, J. I., Coulombe-Huntington, J., Yang, F., Peng, J., Weile, J., Karras, G. I., Wang, Y., et al. (2015) · Cell

Genomics and Rare DiseasesBioinformatics and Genomic Networks

Cited by 594

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences

Antifungal resistance and susceptibilityHeat shock proteins research

Cited by 413

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

Scherz-Shouval, R., Santagata, S., Mendillo, M. L., Sholl, L. M., Ben-Aharon, I., Beck, A. H., Dias-Santagata, D., Koeva, M., Stemmer, S. M., Whitesell, L., et al. (2014) · Cell

Heat shock proteins researchTGF-β signaling in diseases

Cited by 386

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

Vincent, B. M., Lancaster, A. K., Scherz-Shouval, R., Whitesell, L., & Lindquist, S. (2013) · PLoS Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 322

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Whitesell, L., Robbins, N., Huang, D. S., McLellan, C. A., Shekhar-Guturja, T., LeBlanc, E. V., Nation, C. S., Hui, R., Hutchinson, A., Collins, C., et al. (2019) · Nature Communications

Heat shock proteins researchAntifungal resistance and susceptibility

Cited by 124

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

McLellan, C. A., Whitesell, L., King, O. D., Lancaster, A. K., Mazitschek, R., & Lindquist, S. (2012) · ACS Chemical Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 115

2, 3-Dihydrowithaferin A-3β-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera

Xu, Y.-M., Marron, M. T., Seddon, E., McLaughlin, S. P., Ray, D. T., Whitesell, L., & Leslie Gunatilaka, A. A. (2009) · Bioorganic & Medicinal Chemistry

Phytochemicals and Medicinal PlantsPlant tissue culture and regeneration

Cited by 75

Inhibiting HSP90 to treat cancer: a strategy in evolution

Whitesell, L., Santagata, S., & Lin, N. U. (2012) · Current Molecular Medicine

Heat shock proteins researchCancer Mechanisms and Therapy

Cited by 67

A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

Vincent, B. M., Langlois, J.-B., Srinivas, R., Lancaster, A. K., Scherz-Shouval, R., Whitesell, L., Tidor, B., Buchwald, S. L., & Lindquist, S. (2016) · Cell Chemical Biology

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 58

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2

Caplan, T., Lorente-Macías, Á., Stogios, P. J., Evdokimova, E., Hyde, S., Wellington, M. A., Liston, S., Iyer, K. R., Puumala, E., Shekhar-Guturja, T., et al. (2020) · Cell Chemical Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 57

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

McLellan, C. A., Vincent, B. M., Solis, N. V., Lancaster, A. K., Sullivan, L. B., Hartland, C. L., Youngsaye, W., Filler, S. G., Whitesell, L., & Lindquist, S. (2018) · Nature Chemical Biology

Antifungal resistance and susceptibilityMitochondrial Function and Pathology

Cited by 49

Fungal-selective resorcylate aminopyrazole Hsp90 inhibitors: optimization of whole-cell anticryptococcal activity and insights into the structural origins of cryptococcal selectivity

Marcyk, P. T., LeBlanc, E. V., Kuntz, D. A., Xue, A., Ortiz, F., Trilles, R., Bengtson, S., Kenney, T. M. G., Huang, D. S., Robbins, N., et al. (2021) · Journal of Medicinal Chemistry

Heat shock proteins researchFungal Infections and Studies

Cited by 40

Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III

Di Trani, J. M., Liu, Z., Whitesell, L., Brzezinski, P., Cowen, L. E., & Rubinstein, J. L. (2022) · Structure

Enzyme Structure and FunctionMitochondrial Function and Pathology

Cited by 32

Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence

Fu, C., Beattie, S. R., Jezewski, A. J., Robbins, N., Whitesell, L., Krysan, D. J., & Cowen, L. E. (2022) · Genetics

Fungal Infections and StudiesHeat shock proteins research

Cited by 31

Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence

Liu, Z., Basso, P., Hossain, S., Liston, S. D., Robbins, N., Whitesell, L., Noble, S. M., & Cowen, L. E. (2023) · Nature Communications

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 22

Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens

Liston, S. D., Whitesell, L., Kapoor, M., Shaw, K. J., & Cowen, L. E. (2022) · Journal of Fungi

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 12