Ruhwedel, Torben

Defective cholesterol clearance limits remyelination in the aged central nervous system

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 586

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Depp, C., Sun, T., Sasmita, A. O., Spieth, L., Berghoff, S. A., Nazarenko, T., Overhoff, K., Steixner-Kumar, A. A., Subramanian, S., Arinrad, S., et al. (2023) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 493

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Berghoff, S. A., Spieth, L., Sun, T., Hosang, L., Schlaphoff, L., Depp, C., Düking, T., Winchenbach, J., Neuber, J., Ewers, D., et al. (2021) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 307

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

Berghoff, S. A., Gerndt, N., Winchenbach, J., Stumpf, S. K., Hosang, L., Odoardi, F., Ruhwedel, T., Böhler, C., Barrette, B., Stassart, R., et al. (2017) · Nature Communications

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 151

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Weil, M.-T., Möbius, W., Winkler, A., Ruhwedel, T., Wrzos, C., Romanelli, E., Bennett, J. L., Enz, L., Goebels, N., Nave, K.-A., et al. (2016) · Cell Reports

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 142

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

Asadollahi, E., Trevisiol, A., Saab, A. S., Looser, Z. J., Dibaj, P., Ebrahimi, R., Kusch, K., Ruhwedel, T., Möbius, W., Jahn, O., et al. (2024) · Nature Neuroscience

Lipid metabolism and biosynthesisNeurogenesis and neuroplasticity mechanisms

Cited by 130

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Sasmita, A. O., Depp, C., Nazarenko, T., Sun, T., Siems, S. B., Ong, E. C., Nkeh, Y. B., Böhler, C., Yu, X., Bues, B., et al. (2024) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 125

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

Saher, G., Rudolphi, F., Corthals, K., Ruhwedel, T., Schmidt, K.-F., Löwel, S., Dibaj, P., Barrette, B., Möbius, W., & Nave, K.-A. (2012) · Nature Medicine

Multiple Sclerosis Research StudiesLysosomal Storage Disorders Research

Cited by 123

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Meschkat, M., Steyer, A. M., Weil, M.-T., Kusch, K., Jahn, O., Piepkorn, L., Agüi-Gonzalez, P., Phan, N. T. N., Ruhwedel, T., Sadowski, B., et al. (2022) · Nature Communications

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 112

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

Berghoff, S. A., Düking, T., Spieth, L., Winchenbach, J., Stumpf, S. K., Gerndt, N., Kusch, K., Ruhwedel, T., Möbius, W., & Saher, G. (2017) · Acta Neuropathologica Communications

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 100

Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7

Feldmann, A., Amphornrat, J., Schönherr, M., Winterstein, C., Möbius, W., Ruhwedel, T., Danglot, L., Nave, K.-A., Galli, T., Bruns, D., et al. (2011) · The Journal of Neuroscience

Cellular transport and secretionNeurogenesis and neuroplasticity mechanisms

Cited by 99

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

Buscham, T. J., Eichel-Vogel, M. A., Steyer, A. M., Jahn, O., Strenzke, N., Dardawal, R., Memhave, T. R., Siems, S. B., Müller, C., Meschkat, M., et al. (2022) · eLife

Multiple Sclerosis Research StudiesHereditary Neurological Disorders

Cited by 18