Nowotny, Marcin

cGAS surveillance of micronuclei links genome instability to innate immunity

Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 1,752

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis

Nowotny, M., Gaidamakov, S. A., Crouch, R. J., & Yang, W. (2005) · Cell

Enzyme Structure and FunctionDNA and Nucleic Acid Chemistry

Cited by 620

Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity

Yang, W., Lee, J. Y., & Nowotny, M. (2006) · Molecular Cell

DNA and Nucleic Acid ChemistryPhysical Organic Chemistry and Reaction Kinetics

Cited by 573

Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription

Nowotny, M., Gaidamakov, S. A., Ghirlando, R., Cerritelli, S. M., Crouch, R. J., & Yang, W. (2007) · Molecular Cell

Enzyme Structure and FunctionHIV/AIDS drug development and treatment

Cited by 316

Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release

Nowotny, M., & Yang, W. (2006) · The EMBO Journal

Enzyme Structure and FunctionPhysical Organic Chemistry and Reaction Kinetics

Cited by 250

Retroviral integrase superfamily: the structural perspective

Nowotny, M. (2009) · The EMBO Reports

HIV/AIDS drug development and treatmentEnzyme Structure and Function

Cited by 183

Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage

Rychlik, M. P., Chon, H., Cerritelli, S. M., Klimek, P., Crouch, R. J., & Nowotny, M. (2010) · Molecular Cell

Enzyme Structure and FunctionDNA and Nucleic Acid Chemistry

Cited by 109

Structure of human TRPM8 channel

Palchevskyi, S., Czarnocki-Cieciura, M., Vistoli, G., Gervasoni, S., Nowak, E., Beccari, A., Nowotny, M., & Talarico, C. (2023) · Communications Biology

Ion Channels and ReceptorsIon channel regulation and function

Cited by 46

Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists

Pankiewicz, P., Szybiński, M., Kisielewska, K., Gołębiowski, F., Krzemiński, P., Rutkowska-Włodarczyk, I., Moszczyński-Pętkowski, R., Gurba-Bryśkiewicz, L., Delis, M., Mulewski, K., et al. (2021) · Pharmaceuticals

Nerve injury and regenerationTreatment of Major Depression

Cited by 42

Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry

Nowak, E., Miller, J. T., Bona, M. K., Studnicka, J., Szczepanowski, R. H., Jurkowski, J., Le Grice, S. F. J., & Nowotny, M. (2014) · Nature Structural & Molecular Biology

Chromosomal and Genetic VariationsEnzyme Structure and Function

Cited by 31