Christen, Stefan

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Liu, P.-S., Wang, H., Li, X., Chao, T., Teav, T., Christen, S., Di Conza, G., Cheng, W.-C., Chou, C.-H., Vavakova, M., et al. (2017) · Nature Immunology

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 1,264

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Schoors, S., Bruning, U., Missiaen, R., Queiroz, K. C. S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A. R., Christen, S., Goveia, J., et al. (2015) · Nature

Cancer, Lipids, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 646

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

Robitaille, A. M., Christen, S., Shimobayashi, M., Cornu, M., Fava, L. L., Moes, S., Prescianotto-Baschong, C., Sauer, U., Jenoe, P., & Hall, M. N. (2013) · Science

PI3K/AKT/mTOR signaling in cancerBiochemical and Molecular Research

Cited by 525

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Mullarky, E., Lucki, N. C., Beheshti Zavareh, R., Anglin, J. L., Gomes, A. P., Nicolay, B. N., Wong, J. C. Y., Christen, S., Takahashi, H., Singh, P. K., et al. (2016) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 333

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Christen, S., Lorendeau, D., Schmieder, R., Broekaert, D., Metzger, K., Veys, K., Elia, I., Buescher, J. M., Orth, M. F., Davidson, S. M., et al. (2016) · Cell Reports

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 258

Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia

Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., et al. (2024) · Nature Metabolism

Sirtuins and Resveratrol in MedicineNutrition and Health in Aging

Cited by 148

Intracellular characterization of aerobic glucose metabolism in seven yeast species by 13C flux analysis and metabolomics: Flux response to Crabtree effect in yeast species

Christen, S., & Sauer, U. (2011) · FEMS Yeast Research

Fungal and yeast genetics researchMicrobial Metabolic Engineering and Bioproduction

Cited by 147

SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease

Gut, P., Matilainen, S., Meyer, J. G., Pällijeff, P., Richard, J., Carroll, C. J., Euro, L., Jackson, C. B., Isohanni, P., Minassian, B. A., et al. (2020) · Nature Communications

Metabolism and Genetic DisordersMitochondrial Function and Pathology

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