Sharpe, Arlene H.

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

Read, S., Greenwald, R., Izcue, A., Robinson, N., Mandelbrot, D., Francisco, L., Sharpe, A. H., & Powrie, F. (2006) · The Journal of Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

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Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., et al. (2016) · Cell Metabolism

Mitochondrial Function and PathologyT-cell and B-cell Immunology

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CTLA-4 regulates induction of anergy in vivo

Greenwald, R. J., Boussiotis, V. A., Lorsbach, R. B., Abbas, A. K., & Sharpe, A. H. (2001) · Immunity

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

Yergeau, D. A., Hetherington, C. J., Wang, Q., Zhang, P., Sharpe, A. H., Binder, M., Marín-Padilla, M., Tenen, D. G., Speck, N. A., & Zhang, D.-E. (1997) · Nature Genetics

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

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PD-1 Protects against Inflammation and Myocyte Damage in T Cell-Mediated Myocarditis

Tarrio, M. L., Grabie, N., Bu, D.-X., Sharpe, A. H., & Lichtman, A. H. (2012) · The Journal of Immunology

Viral Infections and Immunology ResearchT-cell and B-cell Immunology

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Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities

Pauken, K. E., Dougan, M., Rose, N. R., Lichtman, A. H., & Sharpe, A. H. (2019) · Trends in Immunology

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

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Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms

Moslehi, J., Lichtman, A. H., Sharpe, A. H., Galluzzi, L., & Kitsis, R. N. (2021) · Journal of Clinical Investigation

Cancer Immunotherapy and BiomarkersViral Infections and Immunology Research

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Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

Collier, J. L., Weiss, S. A., Pauken, K. E., Sen, D. R., & Sharpe, A. H. (2021) · Nature Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

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T-cell costimulation–biology, therapeutic potential, and challenges.

Sharpe, A. H., & Abbas, A. K. (2006) · New England Journal of Medicine

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

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Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance

Park, J. S., Gazzaniga, F. S., Wu, M., Luthens, A. K., Gillis, J., Zheng, W., LaFleur, M. W., Johnson, S. B., Morad, G., Park, E. M., et al. (2023) · Nature

Cancer Immunotherapy and BiomarkersGut microbiota and health

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Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

Lombard, D. B., Beard, C., Johnson, B., Marciniak, R. A., Dausman, J., Bronson, R., Buhlmann, J. E., Lipman, R., Curry, R., Sharpe, A., et al. (2000) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

Lo, J. A., Kawakubo, M., Juneja, V. R., Su, M. Y., Erlich, T. H., LaFleur, M. W., Kemeny, L. V., Rashid, M., Malehmir, M., Rabi, S. A., et al. (2021) · Science Translational Medicine

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

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The effects of age and systemic metabolism on anti-tumor T cell responses

Drijvers, J. M., Sharpe, A. H., & Haigis, M. C. (2020) · eLife

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

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Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Rowe, J. H., Elia, I., Shahid, O., Gaudiano, E. F., Sifnugel, N. E., Johnson, S., Reynolds, A. G., Fung, M. E., Joshi, S., LaFleur, M. W., et al. (2023) · Cancer Discovery

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

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Liver stromal cells restrict macrophage maturation and stromal IL-6 limits the differentiation of cirrhosis-linked macrophages

Buonomo, E. L., Mei, S., Guinn, S. R., Leo, I. R., Peluso, M. J., Nolan, M.-A., Schildberg, F. A., Zhao, L., Lian, C., Xu, S., et al. (2022) · Journal of Hepatology

Liver physiology and pathologyLiver Disease and Transplantation

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