Khokha, Rama

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Harris, I. S., Treloar, A. E., Inoue, S., Sasaki, M., Gorrini, C., Lee, K. C., Yung, K. Y., Brenner, D., Knobbe-Thomsen, C. B., Cox, M. A., et al. (2015) · Cancer Cell

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 993

Regulation of cancer cell migration and bone metastasis by RANKL.

Jones, D. H., Nakashima, T., Sanchez, O. H., Kozieradzki, I., Komarova, S. V., Sarosi, I., Morony, S., Rubin, E., Sarao, R., Hojilla, C. V., et al. (2006) · Nature

Mechanisms of cancer metastasisCancer Cells and Metastasis

Cited by 796

The osteoclast differentiation factor osteoprotegerin ligand is essential for mammary gland development.

Fata, J. E., Kong, Y.-Y., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, R. A., Elliott, R., Scully, S., Voura, E. B., Lacey, D. L., et al. (2000) · Cell

Bone Metabolism and DiseasesEstrogen and related hormone effects

Cited by 756

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Hezaveh, K., Shinde, R. S., Klötgen, A., Halaby, M. J., Lamorte, S., Ciudad, M. T., Quevedo, R., Neufeld, L., Liu, Z. Q., Jin, R., et al. (2022) · Immunity

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 746

Suppression of tumor growth and metastasis in Mgat5-deficient mice

Granovsky, M., Fata, J., Pawling, J., Muller, W. J., Khokha, R., & Dennis, J. W. (2000) · Nature Medicine

Glycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis

Cited by 569

Metalloproteinases and their natural inhibitors in inflammation and immunity

Khokha, R., Murthy, A., & Weiss, A. (2013) · Nature reviews. Immunology

Protease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms

Cited by 552

Spatially confined sub-tumor microenvironments in pancreatic cancer

Grünwald, B. T., Devisme, A., Andrieux, G., Vyas, F., Aliar, K., McCloskey, C. W., Macklin, A., Jang, G. H., Denroche, R., Romero, J. M., et al. (2021) · Cell

Pancreatic and Hepatic Oncology ResearchSingle-cell and spatial transcriptomics

Cited by 433

Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State

Sun, M., Chen, M., Dawood, F., Zurawska, U., Li, J. Y., Parker, T., Kassiri, Z., Kirshenbaum, L. A., Arnold, M., Khokha, R., et al. (2007) · Circulation

Cardiac Fibrosis and RemodelingSignaling Pathways in Disease

Cited by 383

GATA6 expression distinguishes classical and basal-like subtypes in advanced pancreatic cancer

O’Kane, G. M., Grünwald, B. T., Jang, G.-H., Masoomian, M., Picardo, S., Grant, R. C., Denroche, R. E., Zhang, A., Wang, Y., Miller, J. K., et al. (2020) · Clinical Cancer Research

Pancreatic and Hepatic Oncology ResearchBreast Cancer Treatment Studies

Cited by 352

Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution

Schenk, S., Hintermann, E., Bilban, M., Koshikawa, N., Hojilla, C., Khokha, R., & Quaranta, V. (2003) · The Journal of Cell Biology

Protease and Inhibitor MechanismsCell Adhesion Molecules Research

Cited by 309

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

Gorrini, C., Baniasadi, P. S., Harris, I. S., Silvester, J., Inoue, S., Snow, B., Joshi, P. A., Wakeham, A., Molyneux, S. D., Martin, B., et al. (2013) · Journal of Experimental Medicine

Genomics, phytochemicals, and oxidative stressBRCA gene mutations in cancer

Cited by 289

A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

Romero, J. M., Grünwald, B., Jang, G.-H., Bavi, P. P., Jhaveri, A., Masoomian, M., Fischer, S. E., Zhang, A., Denroche, R. E., Lungu, I. M., et al. (2020) · Clinical Cancer Research

Pancreatic and Hepatic Oncology ResearchCancer Immunotherapy and Biomarkers

Cited by 146

Individual Timp Deficiencies Differentially Impact Pro-MMP-2 Activation

English, J. L., Kassiri, Z., Koskivirta, I., Atkinson, S. J., Di Grappa, M., Soloway, P. D., Nagase, H., Vuorio, E., Murphy, G., & Khokha, R. (2006) · Journal of Biological Chemistry

Protease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms

Cited by 120

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay

Fiorentino, L., Cavalera, M., Menini, S., Marchetti, V., Mavilio, M., Fabrizi, M., Conserva, F., Casagrande, V., Menghini, R., Pontrelli, P., et al. (2013) · EMBO Molecular Medicine

Chronic Kidney Disease and DiabetesRenal Diseases and Glomerulopathies

Cited by 98