Hewitson, Kirsty S.

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 3,333

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y.-M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M., et al. (2002) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 719

Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α

Elkins, J. M., Hewitson, K. S., McNeill, L. A., Seibel, J. F., Schlemminger, I., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2003) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 391

Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Cockman, M. E., Lancaster, D. E., Stolze, I. P., Hewitson, K. S., McDonough, M. A., Coleman, M. L., Coles, C. H., Yu, X., Hay, R. T., Ley, S. C., et al. (2006) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 285

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

Hewitson, K. S., Liénard, B. M. R., McDonough, M. A., Clifton, I. J., Butler, D., Soares, A. S., Oldham, N. J., McNeill, L. A., & Schofield, C. J. (2007) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 235

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Ehrismann, D., Flashman, E., Genn, D. N., Mathioudakis, N., Hewitson, K. S., Ratcliffe, P. J., & Schofield, C. J. (2007) · Biochemical Journal

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 225

Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor

Coleman, M. L., McDonough, M. A., Hewitson, K. S., Coles, C., Mecinovicí, J., Edelmann, M., Cook, K. M., Cockman, M. E., Lancaster, D. E., Kessler, B. M., et al. (2007) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 222

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

McNEILL, L. A., HEWITSON, K. S., CLARIDGE, T. D., SEIBEL, J. F., HORSFALL, L. E., & SCHOFIELD, C. J. (2002) · Biochemical Journal

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 215

2-Oxoglutarate analogue inhibitors of hif prolyl hydroxylase

Mole, D. R., Schlemminger, I., McNeill, L. A., Hewitson, K. S., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2003) · Bioorganic & Medicinal Chemistry Letters

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 145

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

McNeill, L. A., Hewitson, K. S., Gleadle, J. M., Horsfall, L. E., Oldham, N. J., Maxwell, P. H., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J. (2002) · Bioorganic & Medicinal Chemistry Letters

Metal-Catalyzed Oxygenation MechanismsCancer, Hypoxia, and Metabolism

Cited by 116