Kohlhepp, Marlene

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

Krenkel, O., Puengel, T., Govaere, O., Abdallah, A. T., Mossanen, J. C., Kohlhepp, M., Liepelt, A., Lefebvre, E., Luedde, T., Hellerbrand, C., et al. (2018) · Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 557

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 398

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

Krenkel, O., Hundertmark, J., Abdallah, A. T., Kohlhepp, M., Puengel, T., Roth, T., Branco, D. P. P., Mossanen, J. C., Luedde, T., Trautwein, C., et al. (2020) · Gut

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 220

Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression

Guillot, A., Winkler, M., Silva Afonso, M., Aggarwal, A., Lopez, D., Berger, H., Kohlhepp, M. S., Liu, H., Özdirik, B., Eschrich, J., et al. (2023) · Hepatology

Liver Diseases and ImmunityLiver Disease Diagnosis and Treatment

Cited by 116

Combined therapy with a CCR2/CCR5 antagonist and FGF21 analogue synergizes in ameliorating steatohepatitis and fibrosis

Puengel, T., Lefere, S., Hundertmark, J., Kohlhepp, M., Penners, C., Van de Velde, F., Lapauw, B., Hoorens, A., Devisscher, L., Geerts, A., et al. (2022) · International Journal of Molecular Sciences

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 59

Deciphering the Immune Microenvironment on A Single Archival Formalin-Fixed Paraffin-Embedded Tissue Section by An Immediately Implementable Multiplex Fluorescence Immunostaining Protocol

Guillot, A., Kohlhepp, M., Bruneau, A., Heymann, F., & Tacke, F. (2020) · Cancers

Cancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomics

Cited by 46

Roles of CCR2 and CCR5 for hepatic macrophage polarization in mice with liver parenchymal cell-specific NEMO deletion

Bartneck, M., Koppe, C., Fech, V., Warzecha, K. T., Kohlhepp, M., Huss, S., Weiskirchen, R., Trautwein, C., Luedde, T., & Tacke, F. (2021) · Cellular and Molecular Gastroenterology and Hepatology

Liver physiology and pathologyChemokine receptors and signaling

Cited by 44

Dissecting Acute Drug‐Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver‐On‐A‐Chip Model

Liu, H., Yin, G., Kohlhepp, M. S., Schumacher, F., Hundertmark, J., Hassan, M. I. A., Heymann, F., Puengel, T., Kleuser, B., Mosig, A. S., et al. (2024) · Advanced Science

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 30

The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities

Kohlhepp, M. S., Liu, H., Tacke, F., & Guillot, A. (2023) · Frontiers in Molecular Biosciences

Immune cells in cancerLiver physiology and pathology

Cited by 27

Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming

Liu, H., Yin, G., Franco Leonardi, B., Lan, T., Ait Ahmed, Y., Berger, H., Kohlhepp, M. S., Amiridze, N., Martagón Calderón, N., Frau, C., et al. (2025) · Gut

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 23