Befroy, Douglas

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine

Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Cited by 2,193

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 2,107

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease

Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 1,322

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsLiver Disease Diagnosis and Treatment

Cited by 911

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

Petersen, K. F., Oral, E. A., Dufour, S., Befroy, D., Ariyan, C., Yu, C., Cline, G. W., DePaoli, A. M., Taylor, S. I., Gorden, P., et al. (2002) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 800

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

Petersen, K. F., Dufour, S., Savage, D. B., Bilz, S., Solomon, G., Yonemitsu, S., Cline, G. W., Befroy, D., Zemany, L., Kahn, B. B., et al. (2007) · Proceedings of the National Academy of Sciences

Diabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Cited by 759

The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

Mayerson, A. B., Hundal, R. S., Dufour, S., Lebon, V., Befroy, D., Cline, G. W., Enocksson, S., Inzucchi, S. E., Shulman, G. I., & Petersen, K. F. (2002) · Diabetes

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 647

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z.-X., Dong, J., Mustard, K. J., Hawley, S. A., et al. (2007) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 555

Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

Befroy, D. E., Petersen, K. F., Dufour, S., Mason, G. F., de Graaf, R. A., Rothman, D. L., & Shulman, G. I. (2007) · Diabetes

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 453

Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men

Petersen, K. F., Dufour, S., Feng, J., Befroy, D., Dziura, J., Man, C. D., Cobelli, C., & Shulman, G. I. (2006) · Proceedings of the National Academy of Sciences

Diabetes, Cardiovascular Risks, and LipoproteinsLiver Disease Diagnosis and Treatment

Cited by 403

Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Choi, C. S., Befroy, D. E., Codella, R., Kim, S., Reznick, R. M., Hwang, Y.-J., Liu, Z.-X., Lee, H.-Y., Distefano, A., Samuel, V. T., et al. (2008) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 279