Chen, Yu

Deep learning-based kcat prediction enables improved enzyme-constrained model reconstruction

Li, F., Yuan, L., Lu, H., Li, G., Chen, Y., Engqvist, M. K. M., Kerkhoven, E. J., & Nielsen, J. (2022) · Nature Catalysis

Microbial Metabolic Engineering and BioproductionBioinformatics and Genomic Networks

Cited by 466

Energy metabolism controls phenotypes by protein efficiency and allocation

Chen, Y., & Nielsen, J. (2019) · Proceedings of the National Academy of Sciences

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 156

Genome scale modeling of the protein secretory pathway reveals novel targets for improved recombinant protein production in yeast

Li, F., Chen, Y., Qi, Q., Wang, Y., Yuan, L., Huang, M., Elsemman, I. E., Feizi, A., Kerkhoven, E. J., & Nielsen, J. (2021) · Nature Communications

Microbial Metabolic Engineering and BioproductionFungal and yeast genetics research

Cited by 91

Proteome constraints reveal targets for improving microbial fitness in nutrient‐rich environments

Chen, Y., van Pelt‐KleinJan, E., van Olst, B., Douwenga, S., Boeren, S., Bachmann, H., Molenaar, D., Nielsen, J., & Teusink, B. (2021) · Molecular Systems Biology

Microbial Metabolic Engineering and BioproductionBacterial Genetics and Biotechnology

Cited by 73

Yeast optimizes metal utilization based on metabolic network and enzyme kinetics

Chen, Y., Li, F., Mao, J., Chen, Y., & Nielsen, J. (2021) · Proceedings of the National Academy of Sciences

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 46

Mathematical modeling of proteome constraints within metabolism

Chen, Y., & Nielsen, J. (2021) · Current Opinion in Systems Biology

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 44

Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection

Lu, H., Li, F., Yuan, L., Domenzain, I., Yu, R., Wang, H., Li, G., Chen, Y., Ji, B., Kerkhoven, E. J., et al. (2021) · Molecular Systems Biology

Microbial Metabolic Engineering and BioproductionFungal and yeast genetics research

Cited by 44

Minimization of proteome reallocation explains metabolic transition in hierarchical utilization of carbon sources

Liu, Z., Chen, M., Hu, J., Wang, Y., & Chen, Y. (2024) · mSystems

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 7