Young, Samuel N.

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

Murphy, J. M., Czabotar, P. E., Hildebrand, J. M., Lucet, I. S., Zhang, J.-G., Alvarez-Diaz, S., Lewis, R., Lalaoui, N., Metcalf, D., Webb, A. I., et al. (2013) · Immunity

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,220

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J.-M., Dobson, R. C. J., Webb, A. I., et al. (2014) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 598

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S., & Nicola, N. A. (2012) · Immunity

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 279

Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity

Horne, C. R., Wang, T., Young, S. N., Dite, T. A., Nyvall, H. G., Suresh, S., Davies, K. A., Mather, L. J., Dagley, L. F., Manning, G., et al. (2024) · Biochemical Journal

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 4