Sabeti, Pardis C.

Genome-wide detection and characterization of positive selection in human populations

The International HapMap Consortium, Sabeti, P. C., Varilly, P., Fry, B., Lohmueller, J., Hostetter, E., Cotsapas, C., Xie, X., Byrne, E. H., McCarroll, S. A., et al. (2007) · Nature

Forensic and Genetic ResearchGenetic Associations and Epidemiology

Cited by 2,131

Detecting recent positive selection in the human genome from haplotype structure

Sabeti, P. C., Reich, D. E., Higgins, J. M., Levine, H. Z. P., Richter, D. J., Schaffner, S. F., Gabriel, S. B., Platko, J. V., Patterson, N. J., McDonald, G. J., et al. (2002) · Nature

Forensic and Genetic ResearchGenetic Associations and Epidemiology

Cited by 2,106

Positive Natural Selection in the Human Lineage

Sabeti, P. C., Schaffner, S. F., Fry, B., Lohmueller, J., Varilly, P., Shamovsky, O., Palma, A., Mikkelsen, T. S., Altshuler, D., & Lander, E. S. (2006) · Science

Evolution and Genetic DynamicsForensic and Genetic Research

Cited by 1,157

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

Yurkovetskiy, L., Wang, X., Pascal, K. E., Tomkins-Tinch, C., Nyalile, T. P., Wang, Y., Baum, A., Diehl, W. E., Dauphin, A., Carbone, C., et al. (2020) · Cell

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,025

Neuropathological features of Covid-19

Solomon, I. H., Normandin, E., Bhattacharyya, S., Mukerji, S. S., Keller, K., Ali, A. S., Adams, G., Hornick, J. L., Padera, R. F., & Sabeti, P. (2020) · New England Journal of Medicine

Long-Term Effects of COVID-19Infectious Encephalopathies and Encephalitis

Cited by 815

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

de Bakker, P. I. W., McVean, G., Sabeti, P. C., Miretti, M. M., Green, T., Marchini, J., Ke, X., Monsuur, A. J., Whittaker, P., Delgado, M., et al. (2006) · Nature Genetics

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 766

Common deletion polymorphisms in the human genome

McCarroll, S. A., Hadnott, T. N., Perry, G. H., Sabeti, P. C., Zody, M. C., Barrett, J. C., Dallaire, S., Gabriel, S. B., Lee, C., Daly, M. J., et al. (2006) · Nature Genetics

Genomic variations and chromosomal abnormalitiesGenetic Associations and Epidemiology

Cited by 701

Detecting Natural Selection in Genomic Data

Vitti, J. J., Grossman, S. R., & Sabeti, P. C. (2013) · Annual Review of Genetics

Evolution and Genetic DynamicsGenetic diversity and population structure

Cited by 694

Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

Kotliar, D., Veres, A., Nagy, M. A., Tabrizi, S., Hodis, E., Melton, D. A., & Sabeti, P. C. (2019) · eLife

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 563

A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection

Grossman, S. R., Shylakhter, I., Karlsson, E. K., Byrne, E. H., Morales, S., Frieden, G., Hostetter, E., Angelino, E., Garber, M., Zuk, O., et al. (2010) · Science

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 512

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

Tewhey, R., Kotliar, D., Park, D. S., Liu, B., Winnicki, S., Reilly, S. K., Andersen, K. G., Mikkelsen, T. S., Lander, E. S., Schaffner, S. F., et al. (2016) · Cell

Genetic Associations and EpidemiologyGenomics and Chromatin Dynamics

Cited by 480

Identifying Recent Adaptations in Large-Scale Genomic Data

Grossman, S. R., Andersen, K. G., Shlyakhter, I., Tabrizi, S., Winnicki, S., Yen, A., Park, D. J., Griesemer, D., Karlsson, E. K., Wong, S. H., et al. (2013) · Cell

Genetic Associations and EpidemiologyEvolution and Genetic Dynamics

Cited by 368

Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

Olalde, I., Allentoft, M. E., Sánchez-Quinto, F., Santpere, G., Chiang, C. W. K., DeGiorgio, M., Prado-Martinez, J., Rodríguez, J. A., Rasmussen, S., Quilez, J., et al. (2014) · Nature

Forensic and Genetic ResearchPleistocene-Era Hominins and Archaeology

Cited by 360

Genomic epidemiology reveals multiple introductions of Zika virus into the United States

Grubaugh, N. D., Ladner, J. T., Kraemer, M. U. G., Dudas, G., Tan, A. L., Gangavarapu, K., Wiley, M. R., White, S., Thézé, J., Magnani, D. M., et al. (2017) · Nature

Mosquito-borne diseases and controlViral Infections and Vectors

Cited by 353

Population genetic study of the brain-derived neurotrophic factor (BDNF) gene

Petryshen, T. L., Sabeti, P. C., Aldinger, K. A., Fry, B., Fan, J. B., Schaffner, S. F., Waggoner, S. G., Tahl, A. R., & Sklar, P. (2010) · Molecular Psychiatry

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 267

Integrating gene annotation with orthology inference at scale

Kirilenko, B. M., Munegowda, C., Osipova, E., Jebb, D., Sharma, V., Blumer, M., Morales, A. E., Ahmed, A.-W., Kontopoulos, D.-G., Hilgers, L., et al. (2023) · Science

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 209

Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs

Weingarten-Gabbay, S., Klaeger, S., Sarkizova, S., Pearlman, L. R., Chen, D.-Y., Gallagher, K. M. E., Bauer, M. R., Taylor, H. B., Dunn, W. A., Tarr, C., et al. (2021) · Cell

vaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 Research

Cited by 147

Machine-guided design of cell-type-targeting cis-regulatory elements

Gosai, S. J., Castro, R. I., Fuentes, N., Butts, J. C., Mouri, K., Alasoadura, M., Kales, S., Nguyen, T. T. L., Noche, R. R., Rao, A. S., et al. (2024) · Nature

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 142

Three-dimensional genome rewiring in loci with human accelerated regions

Keough, K. C., Whalen, S., Inoue, F., Przytycki, P. F., Fair, T., Deng, C., Steyert, M., Ryu, H., Lindblad-Toh, K., Karlsson, E., et al. (2023) · Science

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 113

Identifying the favored mutation in a positive selective sweep.

Akbari, A., Vitti, J. J., Iranmehr, A., Bakhtiari, M., Sabeti, P. C., Mirarab, S., & Bafna, V. (2018) · Nature Methods

Evolution and Genetic DynamicsGenetic diversity and population structure

Cited by 95

Discrete SARS-CoV-2 antibody titers track with functional humoral stability

Bartsch, Y. C., Fischinger, S., Siddiqui, S. M., Chen, Z., Yu, J., Gebre, M., Atyeo, C., Gorman, M. J., Zhu, A. L., Kang, J., et al. (2021) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testing

Cited by 82

The adaptive variant EDARV370A is associated with straight hair in East Asians

Tan, J., Yang, Y., Tang, K., Sabeti, P. C., Jin, L., & Wang, S. (2013) · Human Genetics

Hair Growth and DisordersGenetic Associations and Epidemiology

Cited by 72

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

Tewhey, R., Kotliar, D., Park, D. S., Liu, B., Winnicki, S., Reilly, S. K., Andersen, K. G., Mikkelsen, T. S., Lander, E. S., Schaffner, S. F., et al. (2018) · Cell

Genetic Associations and EpidemiologyGenomics and Chromatin Dynamics

Cited by 51

Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells

Jagoda, E., Xue, J. R., Reilly, S. K., Dannemann, M., Racimo, F., Huerta-Sanchez, E., Sankararaman, S., Kelso, J., Pagani, L., Sabeti, P. C., et al. (2022) · Molecular Biology and Evolution

Genetic Associations and EpidemiologyPleistocene-Era Hominins and Archaeology

Cited by 47