Shihabuddin, Lamya S.

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

Kordasiewicz, H. B., Stanek, L. M., Wancewicz, E. V., Mazur, C., McAlonis, M. M., Pytel, K. A., Artates, J. W., Weiss, A., Cheng, S. H., Shihabuddin, L. S., et al. (2012) · Neuron

Genetic Neurodegenerative DiseasesRNA Interference and Gene Delivery

Cited by 770

Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models

Sardi, S. P., Viel, C., Clarke, J., Treleaven, C. M., Richards, A. M., Park, H., Olszewski, M. A., Dodge, J. C., Marshall, J., Makino, E., et al. (2017) · Proceedings of the National Academy of Sciences

Lysosomal Storage Disorders ResearchParkinson's Disease Mechanisms and Treatments

Cited by 203

Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit

Van Alstyne, M., Tattoli, I., Delestrée, N., Recinos, Y., Workman, E., Shihabuddin, L. S., Zhang, C., Mentis, G. Z., & Pellizzoni, L. (2021) · Nature Neuroscience

Neurogenetic and Muscular Disorders ResearchVirus-based gene therapy research

Cited by 188

Cerebrospinal fluid proteomics implicates the granin family in Parkinson’s disease

Rotunno, M. S., Lane, M., Zhang, W., Wolf, P., Oliva, P., Viel, C., Wills, A.-M., Alcalay, R. N., Scherzer, C. R., Shihabuddin, L. S., et al. (2020) · Scientific Reports

Parkinson's Disease Mechanisms and TreatmentsAdvanced Proteomics Techniques and Applications

Cited by 94

Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus

Burgess, A., Wainwright, S. R., Shihabuddin, L. S., Rutishauser, U., Seki, T., & Aubert, I. (2008) · Developmental Neurobiology

Neurogenesis and neuroplasticity mechanismsGlycosylation and Glycoproteins Research

Cited by 65

Rationally designed AAV2 and AAVrh8R capsids provide improved transduction in the retina and brain

Sullivan, J. A., Stanek, L. M., Lukason, M. J., Bu, J., Osmond, S. R., Barry, E. A., O’Riordan, C. R., Shihabuddin, L. S., Cheng, S. H., & Scaria, A. (2018) · Gene Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 37

Gene transfer to the CNS is efficacious in immune-primed mice harboring physiologically relevant titers of anti-AAV antibodies

Treleaven, C. M., Tamsett, T. J., Bu, J., Fidler, J. A., Sardi, S. P., Hurlbut, G. D., Woodworth, L. A., Cheng, S. H., Passini, M. A., Shihabuddin, L. S., et al. (2012) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 31

Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics

Stanek, L. M., Bu, J., & Shihabuddin, L. S. (2019) · Neurobiology of Disease

Genetic Neurodegenerative DiseasesVirus-based gene therapy research

Cited by 15