Hacohen, Nir

A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals

Garber, M., Yosef, N., Goren, A., Raychowdhury, R., Thielke, A., Guttman, M., Robinson, J., Minie, B., Chevrier, N., Itzhaki, Z., et al. (2012) · Molecular Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 369

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Sade-Feldman, M., Yizhak, K., Bjorgaard, S. L., Ray, J. P., de Boer, C. G., Jenkins, R. W., Lieb, D. J., Chen, J. H., Frederick, D. T., Barzily-Rokni, M., et al. (2019) · Cell

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 344

Parsing the interferon transcriptional network and its disease associations

Mostafavi, S., Yoshida, H., Moodley, D., LeBoité, H., Rothamel, K., Raj, T., Ye, C. J., Chevrier, N., Zhang, S.-Y., Feng, T., et al. (2016) · Cell

interferon and immune responsesCytokine Signaling Pathways and Interactions

Cited by 337

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

Verma, V., Shrimali, R. K., Ahmad, S., Dai, W., Wang, H., Lu, S., Nandre, R., Gaur, P., Lopez, J., Sade-Feldman, M., et al. (2019) · Nature Immunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 333

Landscape of tumor-infiltrating T cell repertoire of human cancers

Li, B., Li, T., Pignon, J.-C., Wang, B., Wang, J., Shukla, S. A., Dou, R., Chen, Q., Hodi, F. S., Choueiri, T. K., et al. (2016) · Nature Genetics

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 306

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

Soucie, E. L., Weng, Z., Geirsdóttir, L., Molawi, K., Maurizio, J., Fenouil, R., Mossadegh-Keller, N., Gimenez, G., VanHille, L., Beniazza, M., et al. (2016) · Science

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 263

Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection

Desai, N., Neyaz, A., Szabolcs, A., Shih, A. R., Chen, J. H., Thapar, V., Nieman, L. T., Solovyov, A., Mehta, A., Lieb, D. J., et al. (2020) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 245

In vivo discovery of immunotherapy targets in the tumour microenvironment

Zhou, P., Shaffer, D. R., Alvarez Arias, D. A., Nakazaki, Y., Pos, W., Torres, A. J., Cremasco, V., Dougan, S. K., Cowley, G. S., Elpek, K., et al. (2014) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 237

Intersection of population variation and autoimmunity genetics in human T cell activation

Ye, C. J., Feng, T., Kwon, H.-K., Raj, T., Wilson, M. T., Asinovski, N., McCabe, C., Lee, M. H., Frohlich, I., Paik, H.-I., et al. (2014) · Science

T-cell and B-cell ImmunologyGenetic Associations and Epidemiology

Cited by 236

Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy

Lan, Y. Y., Londoño, D., Bouley, R., Rooney, M. S., & Hacohen, N. (2014) · Cell Reports

Autophagy in Disease and TherapySystemic Lupus Erythematosus Research

Cited by 236

High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies

Rabani, M., Raychowdhury, R., Jovanovic, M., Rooney, M., Stumpo, D. J., Pauli, A., Hacohen, N., Schier, A. F., Blackshear, P. J., Friedman, N., et al. (2014) · Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 226

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

Dubrot, J., Du, P. P., Lane-Reticker, S. K., Kessler, E. A., Muscato, A. J., Mehta, A., Freeman, S. S., Allen, P. M., Olander, K. E., Ockerman, K. M., et al. (2022) · Nature Immunology

Cancer Immunotherapy and BiomarkersImmune Cell Function and Interaction

Cited by 218

Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits

Chevrier, N., Mertins, P., Artyomov, M. N., Shalek, A. K., Iannacone, M., Ciaccio, M. F., Gat-Viks, I., Tonti, E., DeGrace, M. M., Clauser, K. R., et al. (2011) · Cell

Immune Response and Inflammationinterferon and immune responses

Cited by 179

Targeting TBK1 to overcome resistance to cancer immunotherapy

Sun, Y., Revach, O.-Y., Anderson, S., Kessler, E. A., Wolfe, C. H., Jenney, A., Mills, C. E., Robitschek, E. J., Davis, T. G. R., Kim, S., et al. (2023) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 174

Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs

Weingarten-Gabbay, S., Klaeger, S., Sarkizova, S., Pearlman, L. R., Chen, D.-Y., Gallagher, K. M. E., Bauer, M. R., Taylor, H. B., Dunn, W. A., Tarr, C., et al. (2021) · Cell

vaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 Research

Cited by 147

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

Lan, Y. Y., Heather, J. M., Eisenhaure, T., Garris, C. S., Lieb, D., Raychowdhury, R., & Hacohen, N. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 130

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses

Lo, J. A., Kawakubo, M., Juneja, V. R., Su, M. Y., Erlich, T. H., LaFleur, M. W., Kemeny, L. V., Rashid, M., Malehmir, M., Rabi, S. A., et al. (2021) · Science Translational Medicine

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 97

Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis

Cui, A., Li, B., Wallace, M. S., Gonye, A. L. K., Oetheimer, C., Patel, H., Tonnerre, P., Holmes, J. A., Lieb, D., Yao, B. S., et al. (2024) · Journal of Hepatology

Hepatitis C virus researchSingle-cell and spatial transcriptomics

Cited by 46

Targeting individual cells by barcode in pooled sequence libraries

Ranu, N., Villani, A.-C., Hacohen, N., & Blainey, P. C. (2019) · Nucleic Acids Research

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

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