Mingozzi, Federico

Capsid-specific removal of circulating antibodies to adeno-associated virus vectors

Bertin, B., Veron, P., Leborgne, C., Deschamps, J.-Y., Moullec, S., Fromes, Y., Collaud, F., Boutin, S., Latournerie, V., van Wittenberghe, L., et al. (2020) · Scientific Reports

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 100

Undetectable transcription of cap in a clinical AAV vector: implications for preformed capsid in immune responses

Hauck, B., Murphy, S. L., Smith, P. H., Qu, G., Liu, X., Zelenaia, O., Mingozzi, F., Sommer, J. M., High, K. A., & Wright, J. F. (2009) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 88

Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood

Smith, C. J., Ross, N., Kamal, A., Kim, K. Y., Kropf, E., Deschatelets, P., Francois, C., Quinn, W. J., Singh, I., Majowicz, A., et al. (2022) · Frontiers in Immunology

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 86

AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes

Hui, D. J., Edmonson, S. C., Podsakoff, G. M., Pien, G. C., Ivanciu, L., Camire, R. M., Ertl, H., Mingozzi, F., High, K. A., & Basner-Tschakarjan, E. (2015) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 84

Low-dose liver-targeted gene therapy for pompe disease enhances therapeutic efficacy of ERT via immune tolerance induction

Han, S.-O., Ronzitti, G., Arnson, B., Leborgne, C., Li, S., Mingozzi, F., & Koeberl, D. (2017) · Molecular Therapy - Methods & Clinical Development

Lysosomal Storage Disorders ResearchVirus-based gene therapy research

Cited by 78

The Effect of CpG Sequences on Capsid-Specific CD8+ T Cell Responses to AAV Vector Gene Transfer

Xiang, Z., Kurupati, R. K., Li, Y., Kuranda, K., Zhou, X., Mingozzi, F., High, K. A., & Ertl, H. C. J. (2020) · Molecular Therapy

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 67

A Phase 1/2 Trial of Investigational Spk-8011 in Hemophilia a Demonstrates Durable Expression and Prevention of Bleeds

High, K. A., George, L. A., Eyster, M. E., Sullivan, S. K., Ragni, M. V., Croteau, S. E., Samelson-Jones, B. J., Evans, M., Joseney-Antoine, M., Macdougall, A., et al. (2018) · Blood

Hemophilia Treatment and ResearchVirus-based gene therapy research

Cited by 57

Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes

Hui, D. J., Basner-Tschakarjan, E., Chen, Y., Davidson, R. J., Buchlis, G., Yazicioglu, M., Pien, G. C., Finn, J. D., Haurigot, V., Tai, A., et al. (2013) · Molecular Therapy

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 47

Complement System Response to Adeno-Associated Virus Vector Gene Therapy

Kropf, E., Markusic, D. M., Majowicz, A., Mingozzi, F., & Kuranda, K. (2024) · Human Gene Therapy

Virus-based gene therapy researchComplement system in diseases

Cited by 39

AAV vectors trigger DNA damage responses and STING-dependent inflammation in human CNS cells

Costa-Verdera, H., Meneghini, V., Fitzpatrick, Z., Alezz, M. A., Fabyanic, E., Huang, X., Dzhashiashvili, Y., Ahiya, A., Mangiameli, E., Valeri, E., et al. (2024) · Nature Communications

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 32

AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain

Costa-Verdera, H., Meneghini, V., Fitzpatrick, Z., Abou Alezz, M., Fabyanic, E., Huang, X., Dzhashiashvili, Y., Ahiya, A., Mangiameli, E., Valeri, E., et al. (2025) · Nature Communications

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 32