Lu, Shaoyong

Ras Conformational Ensembles, Allostery, and Signaling

Lu, S., Jang, H., Muratcioglu, S., Gursoy, A., Keskin, O., Nussinov, R., & Zhang, J. (2016) · Chemical Reviews

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 355

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B

Lu, S., Jang, H., Nussinov, R., & Zhang, J. (2016) · Scientific Reports

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 219

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

Lu, S., Jang, H., Gu, S., Zhang, J., & Nussinov, R. (2016) · Chemical Society Reviews

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 188

ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks

Shen, Q., Wang, G., Li, S., Liu, X., Lu, S., Chen, Z., Song, K., Yan, J., Geng, L., Huang, Z., et al. (2016) · Nucleic Acids Research

Receptor Mechanisms and SignalingProtein Structure and Dynamics

Cited by 122

Emerging roles of allosteric modulators in the regulation of protein‐protein interactions (PPIs): A new paradigm for PPI drug discovery

Ni, D., Lu, S., & Zhang, J. (2019) · Medicinal Research Reviews

Chemical Synthesis and AnalysisComputational Drug Discovery Methods

Cited by 116

Recent computational advances in the identification of allosteric sites in proteins

Lu, S., Huang, W., & Zhang, J. (2014) · Drug Discovery Today

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 102

Drugging K-RasG12C through covalent inhibitors: Mission possible?

Ni, D., Li, X., He, X., Zhang, H., Zhang, J., & Lu, S. (2019) · Pharmacology & Therapeutics

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 73

Inhibitors of Ras–SOS Interactions

Lu, S., Jang, H., Zhang, J., & Nussinov, R. (2016) · ChemMedChem

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 72