Klein, Hans-Ulrich

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

Schenk, T., Chen, W. C., Göllner, S., Howell, L., Jin, L., Hebestreit, K., Klein, H.-U., Popescu, A. C., Burnett, A., Mills, K., et al. (2012) · Nature Medicine

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 672

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

De Jager, P. L., Ma, Y., McCabe, C., Xu, J., Vardarajan, B. N., Felsky, D., Klein, H.-U., White, C. C., Peters, M. A., Lodgson, B., et al. (2018) · Scientific Data

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 598

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

Mostafavi, S., Gaiteri, C., Sullivan, S. E., White, C. C., Tasaki, S., Xu, J., Taga, M., Klein, H.-U., Patrick, E., Komashko, V., et al. (2018) · Nature Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 509

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

Ng, B., White, C. C., Klein, H.-U., Sieberts, S. K., McCabe, C., Patrick, E., Xu, J., Yu, L., Gaiteri, C., Bennett, D. A., et al. (2017) · Nature Neuroscience

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 452

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Sieberts, S. K., Perumal, T. M., Carrasquillo, M. M., Allen, M., Reddy, J. S., Hoffman, G. E., Dang, K. K., Calley, J., Ebert, P. J., Eddy, J., et al. (2020) · Scientific Data

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 318

Tau Activates Transposable Elements in Alzheimer’s Disease

Guo, C., Jeong, H.-H., Hsieh, Y.-C., Klein, H.-U., Bennett, D. A., De Jager, P. L., Liu, Z., & Shulman, J. M. (2018) · Cell Reports

Alzheimer's disease research and treatmentsChromosomal and Genetic Variations

Cited by 315

Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

Wan, Y.-W., Al-Ouran, R., Mangleburg, C. G., Perumal, T. M., Lee, T. V., Allison, K., Swarup, V., Funk, C. C., Gaiteri, C., Allen, M., et al. (2020) · Cell Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 295

Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease

Green, G. S., Fujita, M., Yang, H.-S., Taga, M., Cain, A., McCabe, C., Comandante-Lou, N., White, C. C., Schmidtner, A. K., Zeng, L., et al. (2024) · Nature

Single-cell and spatial transcriptomicsAlzheimer's disease research and treatments

Cited by 204

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

Taga, M., Petyuk, V. A., White, C., Marsh, G., Ma, Y., Klein, H.-U., Connor, S. M., Kroshilina, A., Yung, C. J., Khairallah, A., et al. (2020) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 81

The epigenome in Alzheimer’s disease: current state and approaches for a new path to gene discovery and understanding disease mechanism

Klein, H.-U., Bennett, D. A., & De Jager, P. L. (2016) · Acta Neuropathologica

Epigenetics and DNA MethylationAlzheimer's disease research and treatments

Cited by 49

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology

Yang, H.-S., White, C. C., Klein, H.-U., Yu, L., Gaiteri, C., Ma, Y., Felsky, D., Mostafavi, S., Petyuk, V. A., Sperling, R. A., et al. (2020) · Neuron

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 47

A cortical immune network map identifies a subset of human microglia involved in Tau pathology

Patrick, E., Olah, M., Taga, M., Klein, H.-U., Xu, J., White, C. C., Felsky, D., Gaiteri, C., Chibnik, L. B., Mostafavi, S., et al. (2017) · Translational Psychiatry

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 39

Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex

Fujita, M., Gao, Z., Zeng, L., McCabe, C., White, C. C., Ng, B., Green, G. S., Rozenblatt-Rosen, O., Phillips, D., Amir-Zilberstein, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory)

Genetic Associations and EpidemiologySingle-cell and spatial transcriptomics

Cited by 36

A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Patrick, E., Olah, M., Taga, M., Klein, H.-U., Xu, J., White, C. C., Felsky, D., Agrawal, S., Gaiteri, C., Chibnik, L. B., et al. (2021) · Translational Psychiatry

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 31

Proteome-wide Analyses Identified Cortical Proteins Associated With Resilience for Varied Cognitive Abilities

Zammit, A. R., Klein, H.-U., Yu, L., Levey, A. I., Seyfried, N. T., Wingo, A. P., Wingo, T. S., Schneider, J. A., Bennett, D. A., & Buchman, A. S. (2024) · Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 6